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DB00744 : zileuton

Approved drug zileuton ... 1 target DB00744

Generic name: zileuton
 
Brand name(s): leutrol, zyflo, zyflo cr.
Formula: C11H12N2O2S
IUPAC Formula: 1-[1-(1-Benzothiophen-2-Yl)ethyl]-1-Hydroxyurea

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
Links  
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Target proteins

DrugBank drug Target 1:   UniProt id: P09917 (LOX5_HUMAN)  -  Arachidonate 5-lipoxygenase
UniProt id: P09917    673 a.a.  
1. 2abv A     673 a.a. 673   Theor. model
  2. 3o8y A,B     676 a.a. 658   X-ray 2.39 Å
  3. 3v92 B,A     670 a.a. 658   X-ray 2.74 Å
  4. 3v98 A,B     669 a.a. 657   X-ray 2.07 Å
  5. 3v99 A,B     630 a.a. 618   X-ray 2.25 Å
There are no PDB entries containing zileuton bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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