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DB00733 : pralidoxime

Approved drug pralidoxime ... 2 targets DB00733

Generic name: pralidoxime
 
Brand name(s): combopen, protopam.
Formula: C7H9N2O
IUPAC Formula: 2-[(1e)-(Hydroxyimino)methyl]-1-Methylpyridin-1-Ium

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P22303 (ACES_HUMAN)  -  Acetylcholinesterase
UniProt id: P22303    613 a.a.  
1. 4bdt A     563 a.a. 563   X-ray 3.10 Å
  2. 1clj       538 a.a. 538   Theor. model
  3. 1puv A     538 a.a. 538   Theor. model
  4. 1puw A     538 a.a. 538   Theor. model
  5. 2x8b A     536 a.a. 535   X-ray 2.95 Å
   more ...
There are no PDB entries containing pralidoxime bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P06276 (CHLE_HUMAN)  -  Cholinesterase
UniProt id: P06276    601 a.a.  
1. 3o9m A,B     531 a.a. 531   X-ray 2.98 Å
  2. 4aqd A,B     527 a.a. 527   X-ray 2.50 Å
  3. 2pm8 A,B     530 a.a. 527   X-ray 2.80 Å
  4. 2wij A     527 a.a. 524   X-ray 2.10 Å
  5. 2wik A     527 a.a. 524   X-ray 2.10 Å
   more ...
There are no PDB entries containing pralidoxime bound to this target protein, although there are 38 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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