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DB00731 : nateglinide

Approved drug nateglinide ... 2 targets DB00731

Generic name: nateglinide
 
Brand name(s): fastic, starlix, starsis.
Formula: C19H27No3
IUPAC Formula: (2r)-3-Phenyl-2-{[4-(Propan-2-Yl)cyclohexyl]formamido}propanoic acid

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q09428 (ABCC8_HUMAN)  -  ATP-binding cassette transporter sub-family C member 8
UniProt id: Q09428    1581 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P37231 (PPARG_HUMAN)  -  Peroxisome proliferator-activated receptor gamma
UniProt id: P37231    504 a.a.  
1. 3e00 D     363 a.a. 363   X-ray 3.10 Å
  2. 3dzu D     359 a.a. 359   X-ray 3.20 Å
  3. 3dzy D     354 a.a. 354   X-ray 3.10 Å
  4. 3ty0 A,B     277 a.a. 275   X-ray 2.00 Å
  5. 3adx A     274 a.a. 274   X-ray 1.95 Å
   more ...
There are no PDB entries containing nateglinide bound to this target protein, although there are 125 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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