DB00730 : thiabendazole

Approved drug thiabendazole ... 1 target DB00730

Generic name: thiabendazole PDB Het Group: TMG
2 structures in PDB
Brand name(s): apl-luster, arbotect, bioguard, bovizole, chemviron tk 100, cropasal, drawipas, eprofil, equivet tz, equizole, hokustar hp, hymush, lombristop, mertec, mertect, mertect 160, mertect 340f, mertect lsp, metasol tk 10, metasol tk 100, mintesol, mintezol, minzolum, mycozol, nemacin, nemapan, omnizole, ormogal, polival, rph, sanaizol 100, sistesan, storite, tbz 6, tbz 60w, tebuzate, tecto, tecto 10p, tecto 40f, tecto 60, tecto b, tecto rph, testo, thiaben, thibendole, thibenzol, thibenzole, thibenzole 200, thibenzole att, thiprazole, tiabenda, tibimix 20, tobaz, top form wormer, triasox, tubazole.
Formula: C10H7N3S
IUPAC Formula: 2-(1,3-Thiazol-4-Yl)-1h-1,3-Benzodiazole
PDB name: 2-(1,3-Thiazol-4-Yl)-1h-Benzimidazole

There is 1 target protein defined in DrugBank for this drug.
The target protein has one or more structures in the PDB.
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
KEGG drug
Ligand Expo
Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Thiabendazole also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.', WIDTH, 240, PADDING, 4, BGCOLOR, '#ffffff')">Pharmacology


Target proteins

DrugBank drug Target 1:   UniProt id: P00363 (FRDA_ECOLI)  -  Fumarate reductase flavoprotein subunit
UniProt id: P00363    601 a.a.  
1. 1kf6 A,M     577 a.a. 576   X-ray 2.70 Å
  2. 3p4p A,M     577 a.a. 576   X-ray 2.80 Å
  3. 4kx6 A,M     577 a.a. 576   X-ray 2.95 Å
  4. 3p4r A,M     577 a.a. 576   X-ray 3.05 Å
  5. 3p4s A,M     577 a.a. 576   X-ray 3.10 Å
   more ...
There are no PDB entries containing thiabendazole bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule


Other proteins with thiabendazole bound in the PDB

There are 2 "non-target" proteins in the PDB containing the thiabendazole molecule bound. That is, the UniProt code for the proteins is missing or does not match the drug target above.

Protein 1:   UniProt id: P0AE18 ()  -  Methionine aminopeptidase OS=Escherichia coli (strain K12) GN=map PE=1 SV=1
UniProt id: P0AE18    263 a.a.  
1yvm A   262 a.a. 261   X-ray 1.60 Å
The PDB contains 1 entry of thiabendazole bound to this protein
Protein 2:   UniProt id: Q007T0 ()  -  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Sus scrofa GN=SDHB PE=1 SV=1
UniProt id: Q007T0    279 a.a.  
3sfe B   240 a.a. 240   X-ray 2.81 Å
The PDB contains 1 entry of thiabendazole bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.


Structure selection

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LIGPLOT diagrams
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