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DB00704 : naltrexone

Approved drug naltrexone ... 4 targets DB00704

Generic name: naltrexone
 
Brand name(s): celupan, morviva, n-cyclopropylmethylnoroxymorphone, naltrexona [inn-spanish], naltrexone hcl, naltrexone [usan:ban:inn], naltrexonum [inn-latin], revia, vivitrex.
Formula: C20H23No4
IUPAC Formula: (1s,5r,13r,17s)-4-(Cyclopropylmethyl)-10,17-Dihydroxy-12-Oxa-4-
Azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-Trien-14-One

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
Links  
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Target proteins

DrugBank drug Target 1:   UniProt id: P41143 (OPRD_HUMAN)  -  Delta-type opioid receptor
UniProt id: P41143    371 a.a.  
1ozc A     268 a.a. 268   Theor. model
There are no PDB entries containing naltrexone bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P35372 (OPRM_HUMAN)  -  Mu-type opioid receptor
UniProt id: P35372    400 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P41145 (OPRK_HUMAN)  -  Kappa-type opioid receptor
UniProt id: P41145    379 a.a.  
2a0d A     380 a.a. 378   Theor. model
There are no PDB entries containing naltrexone bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q5T1J1 (Q5T1J1_HUMAN)  -  Opioid receptor, sigma 1
UniProt id: Q5T1J1    134 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

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