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DB00695 : furosemide

Approved drug furosemide ... 2 targets DB00695

Generic name: furosemide PDB Het Group: FUN
 
3 structures in PDB
Brand name(s): aisemide, aldalix, aldic, aluzine, anfuramaide, apo-frusemide, apo-furosemide, aquarid, aquasin, arasemide, beronald, bioretic, bristab, bristurin, cetasix, depix, desal, desdemin, di-ademil, dirine, disal, discoid, disemide, diucardin, diumide-k, diural, diurapid, diuretic salt, diurin, diurolasa, diusemide, diusil, diuzol, dranex, dryptal, durafurid, edemid, edenol, eliur, elodrine, endural, errolon, eutensin, farsix, finuret, fluidrol, fluss, franyl, frumex, frumide, frusedan, frusema, frusemin, frusenex, frusetic, frusid, fulsix, fuluvamide, fuluvamine, furanthril, furanthryl, furantril, furanturil, furesis, furetic, furex, furfan, furix, furmid, furo-basan, furo-puren, furobeta, furocot, furodiurol, furodrix, furomen, furomex, furomide m.d., furorese, furosan, furose, furosedon, furosemix, furoside, furosifar, furosix, furoter, furovite, fursol, fusid, golan, hissuflux, hydol, hydrenox, hydrex, hydro, hydro-rapid, hydroled, impugan, jenafusid, katlex, kofuzon, kolkin, kutrix, lasemid, lasex, lasiletten, lasilix, lasix, lasix retard, lasix special, laxur, lazix, leodrine, less diur, liside, logirene, lowpston, lowpstron, luscek, macasirool, marsemide, mirfat, mita, moilarorin, myrosemide, nadis, nelsix, neo-renal, novosemide, odemase, odemex, oedemex, olmagran, polysquall a, prefemin, profemin, promedes, promide, protargen, puresis, radisemide, radonna, radouna, retep, rodiuran, rontyl, rosemide, rosis, rusyde, sal diureticum, salinex, salix, salurex, salurid, saluron, seguril, selectofur, sigasalur, sisuril, spirofur, synephron, transit, trofurit, uremide, uresix, urex, urex-m, urian, uridon, uritol, urosemide, vergonil, vesix, yidoli, zafimida.
Formula: C12H11Cln2O5S
IUPAC Formula: 4-Chloro-2-[(Furan-2-Ylmethyl)amino]-5-Sulfamoylbenzoic acid
PDB name: 5-(Aminosulfonyl)-4-Chloro-2-[(2-Furylmethyl)amino]benzoic acid

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q13621 (S12A1_HUMAN)  -  Solute carrier family 12 member 1
UniProt id: Q13621    1099 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1z9y A   256 a.a. 256   X-ray 1.66 Å
The PDB contains 1 entry of furosemide bound to this target protein and 479 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with furosemide bound in the PDB

There are 2 "non-target" proteins in the PDB containing the furosemide molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: A4GRE3 ()  -  Macrophage migration inhibitory factor OS=Ancylostoma ceylanicum PE=1 SV=1
UniProt id: A4GRE3    118 a.a.  
3rf4 A,B,C   116 a.a. 116   X-ray 1.80 Å
The PDB contains 1 entry of furosemide bound to this protein
Protein 2:   UniProt id: P05543 ()  -  Thyroxine-binding globulin OS=Homo sapiens GN=SERPINA7 PE=1 SV=2
UniProt id: P05543    414 a.a.  
2xn5 A   342 a.a. 332   X-ray 1.70 Å
The PDB contains 1 entry of furosemide bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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