spacer
spacer

Search 

DB00683 : midazolam

Approved drug midazolam ... 19 targets DB00683

Generic name: midazolam PDB Het Group: 08J
 
1 structure in PDB
Brand name(s): dormicum, versed.
Formula: C18H13Clfn3
IUPAC Formula: 12-Chloro-9-(2-Fluorophenyl)-3-Methyl-2,4,8-Triazatricyclo[8.4.0.0^{2,6}]tetradeca-
1(10),3,5,8,11,13-Hexaene
PDB name: 8-Chloro-6-(2-Fluorophenyl)-1-Methyl-4h-Imidazo[1,5-A][1,4]benzodiazepine

19
There are 19 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
RxList
KEGG drug
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: Q8N1C3 (GBRG1_HUMAN)  -  Gamma-aminobutyric acid receptor subunit gamma-1
UniProt id: Q8N1C3    465 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P18507 (GBRG2_HUMAN)  -  Gamma-aminobutyric acid receptor subunit gamma-2
UniProt id: P18507    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q99928 (GBRG3_HUMAN)  -  Gamma-aminobutyric acid receptor subunit gamma-3
UniProt id: Q99928    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: O14764 (GBRD_HUMAN)  -  Gamma-aminobutyric acid receptor subunit delta
UniProt id: O14764    452 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P78334 (GBRE_HUMAN)  -  Gamma-aminobutyric acid receptor subunit epsilon
UniProt id: P78334    506 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: O00591 (GBRP_HUMAN)  -  Gamma-aminobutyric acid receptor subunit pi
UniProt id: O00591    440 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P24046 (GBRR1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit rho-1
UniProt id: P24046    479 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P28476 (GBRR2_HUMAN)  -  Gamma-aminobutyric acid receptor subunit rho-2
UniProt id: P28476    490 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: A8MPY1 (GBRR3_HUMAN)  -  Gamma-aminobutyric acid receptor subunit rho-3
UniProt id: A8MPY1    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: Q9UN88 (GBRT_HUMAN)  -  Gamma-aminobutyric acid receptor subunit theta
UniProt id: Q9UN88    632 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: P14867 (GBRA1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-1
UniProt id: P14867    456 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 12:   UniProt id: P47869 (GBRA2_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-2
UniProt id: P47869    451 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 13:   UniProt id: P34903 (GBRA3_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-3
UniProt id: P34903    492 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 14:   UniProt id: P48169 (GBRA4_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-4
UniProt id: P48169    554 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 15:   UniProt id: P31644 (GBRA5_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-5
UniProt id: P31644    462 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 16:   UniProt id: P18505 (GBRB1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit beta-1
UniProt id: P18505    474 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 17:   UniProt id: P28472 (GBRB3_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit beta-3
UniProt id: P28472    472 a.a.  
4cof A,B,C,D,E     340 a.a. 309   X-ray 2.97 Å
There are no PDB entries containing midazolam bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 18:   UniProt id: P47870 (GBRB2_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit beta-2
UniProt id: P47870    512 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 19:   UniProt id: Q16445 (GBRA6_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-6
UniProt id: Q16445    453 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with midazolam bound in the PDB

There is 1 "non-target" protein in the PDB containing the midazolam molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: O60885 ()  -  Bromodomain-containing protein 4 OS=Homo sapiens GN=BRD4 PE=1 SV=2
UniProt id: O60885    1361 a.a.  
3u5k A,B,C,D   126 a.a. 125   X-ray 1.80 Å
The PDB contains 1 entry of midazolam bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer