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DB00675 : tamoxifen

Approved drug tamoxifen ... 2 targets DB00675

Generic name: tamoxifen PDB Het Group: CTX
 
1 structure in PDB
Brand name(s): citofen, crisafeno, diemon, gen-tamoxifen, istubol, noltam, nolvadex, nolvadex-d, nourytam, novo-tamoxifen, oncomox, pms-tamoxifen, retaxim, soltamox, tamizam, tamofen, tamone, tamoxasta, tamoxen, valodex, zemide.
Formula: C26H29No
IUPAC Formula: (2-{4-[(1z)-1,2-Diphenylbut-1-En-1-Yl]phenoxy}ethyl)dimethylamine
PDB name: (Z)-2-[4-(1,2)-Diphenyl-1-Butenyl)-Phenoxy]-N,N-Dimethylethanamine

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P03372 (ESR1_HUMAN)  -  Estrogen receptor
UniProt id: P03372    594 a.a.  
1. 1qku A,B,C     250 a.a. 250   X-ray 3.20 Å
  2. 3ert A     247 a.a. 247   X-ray 1.90 Å
  3. 1g50 A,B,C     247 a.a. 247   X-ray 2.90 Å
  4. 2ouz A     246 a.a. 246   X-ray 2.00 Å
  5. 3erd A,B     246 a.a. 246   X-ray 2.03 Å
   more ...
There are no PDB entries containing tamoxifen bound to this target protein, although there are 102 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q92731 (ESR2_HUMAN)  -  Estrogen receptor beta
UniProt id: Q92731    529 a.a.  
1. 3oll A,B     234 a.a. 233   X-ray 1.50 Å
  2. 1l2j A,B     232 a.a. 232   X-ray 2.95 Å
  3. 1u3r A,B     231 a.a. 231   X-ray 2.21 Å
  4. 1nde A     231 a.a. 231   X-ray 3.00 Å
  5. 1qkm A     230 a.a. 230   X-ray 1.80 Å
   more ...
There are no PDB entries containing tamoxifen bound to this target protein, although there are 30 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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