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DB00668 : epinephrine

Approved drug epinephrine ... 8 targets DB00668

Generic name: epinephrine PDB Het Group: ALE
 
3 structures in PDB
Brand name(s): adrop, adnephrine, adrenal, adrenalin-medihaler, adrenamine, adrenan, adrenapax, adrenasol, adrenatrate, adrenine, adrenodis, adrenohorma, adrenor, adrenosan, adrenutol, adrin, adrine, aktamin, ana-guard, antiasthmatique, asmatane mist, asthma meter mist, asthma-nefrin, asthmahaler mist, asthmanefrin, astmahalin, astminhal, balmadren, bernarenin, biorenine, bosmin, brevirenin, bronkaid, bronkaid mist, bronkaid suspension mist, chelafrin, citanest forte, corisol, drenamist, duranest, dylephrin, epi ez pen jr, epifrin, epiglaufrin, epipen, epipen auto-injector, epipen ez pen, epipen jr., epipen jr. auto-injector, epirenamine, epirenan, epirenin, epitrate, eppy, esphygmogenina, exadrin, glaucon, glaucosan, glauposine, glycirenan, haemostasin, haemostatin, hektalin, hemisine, hemostasin, hemostatin, hypernephrin, hyporenin, iop, intranefrin, iontocaine, isoptoepinal, kidoline, levonor, levorenen, levorenin, levorenine, lidocaton, lyophrin, medihaler-epi, metanephrin, micronefrin, mucidrina, myosthenine, mytrate, nephridine, nieraline, paranephrin, primatene mist, renagladin, renaglandin, renaglandulin, renaleptine, renalina, renoform, renostypricin, renostypticin, renostyptin, scurenaline, septocaine, simplene, sindrenina, soladren, sphygmogenin, stryptirenal, styptirenal, supracapsulin, supradin, supranefran, supranephrane, supranephrine, supranol, suprarenaline, suprarenin, suprel, surenine, surrenine, sus-phrine, susphrine, sympathin e, sympathin i, takamina, takamine, tokamina, tolansin, tolax, tolcil, tolhart, tonogen, twinject, vaponefrin, vasoconstrictine, vasodrine, vasoton, vasotonin.
Formula: C9H13No3
IUPAC Formula: 4-[(1r)-1-Hydroxy-2-(Methylamino)ethyl]benzene-1,2-Diol
PDB name: L-Epinephrine

8
There are 8 target proteins defined in DrugBank for this drug.
 5 
5 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
UniProt id: P35368    520 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P08588 (ADRB1_HUMAN)  -  Beta-1 adrenergic receptor
UniProt id: P08588    476 a.a.  
2lsq A     25 a.a. 19   NMR  
There are no PDB entries containing epinephrine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 4:   UniProt id: P07550 (ADRB2_HUMAN)  -  Beta-2 adrenergic receptor
UniProt id: P07550    412 a.a.  
1. 3pds A     442 a.a. 292   X-ray 3.50 Å
  2. 4gbr A     286 a.a. 283   X-ray 3.99 Å
  3. 3kj6 A     222 a.a. 222   X-ray 3.40 Å
  4. 2r4r A     216 a.a. 216   X-ray 3.40 Å
  5. 2r4s A     216 a.a. 216   X-ray 3.40 Å
   more ...
There are no PDB entries containing epinephrine bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P08913 (ADA2A_HUMAN)  -  Alpha-2A adrenergic receptor
UniProt id: P08913    449 a.a.  
1. 1hll A     32 a.a. 32   NMR  
  2. 1hof A     32 a.a. 32   NMR  
  3. 1ho9 A     32 a.a. 31   NMR  
  4. 1hod A     32 a.a. 31   NMR  
There are no PDB entries containing epinephrine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P18089 (ADA2B_HUMAN)  -  Alpha-2B adrenergic receptor
UniProt id: P18089    449 a.a.  
2cva A     32 a.a. 32   Theor. model
There are no PDB entries containing epinephrine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: P25100 (ADA1D_HUMAN)  -  Alpha-1D adrenergic receptor
UniProt id: P25100    572 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P00439 (PH4H_HUMAN)  -  Phenylalanine-4-hydroxylase
UniProt id: P00439    451 a.a.  
1. 2pah A,B     329 a.a. 329   X-ray 3.10 Å
  2. 1mmk A     309 a.a. 309   X-ray 2.00 Å
  3. 4anp A     309 a.a. 309   X-ray 2.11 Å
  4. 1mmt A     308 a.a. 308   X-ray 2.00 Å
  5. 1pah A     308 a.a. 308   X-ray 2.00 Å
   more ...
There are no PDB entries containing epinephrine bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with epinephrine bound in the PDB

There is 1 "non-target" protein in the PDB containing the epinephrine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P00441 ()  -  Superoxide dismutase [Cu-Zn] OS=Homo sapiens GN=SOD1 PE=1 SV=2
UniProt id: P00441    153 a.a.  
4a7u A,F   153 a.a. 152   X-ray
The PDB contains 1 entry of epinephrine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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