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DB00659 : acamprosate

Approved drug acamprosate ... 5 targets DB00659

Generic name: acamprosate
 
Brand name(s): campral.
Formula: C5H11No4S
IUPAC Formula: 3-Acetamidopropane-1-Sulfonic acid

5
There are 5 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q8TCU5 (NMD3A_HUMAN)  -  Glutamate [NMDA] receptor subunit 3A
UniProt id: Q8TCU5    1115 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P41594 (GRM5_HUMAN)  -  Metabotropic glutamate receptor 5
UniProt id: P41594    1211 a.a.  
3lmk A,B     438 a.a. 437   X-ray 2.44 Å
There are no PDB entries containing acamprosate bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q13255 (GRM1_HUMAN)  -  Metabotropic glutamate receptor 1
UniProt id: Q13255    1193 a.a.  
3ks9 A,B     445 a.a. 444   X-ray 1.90 Å
There are no PDB entries containing acamprosate bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q14416 (GRM2_HUMAN)  -  Metabotropic glutamate receptor 2
UniProt id: Q14416    872 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q14832 (GRM3_HUMAN)  -  Metabotropic glutamate receptor 3
UniProt id: Q14832    878 a.a.  
1. 1s8m A     445 a.a. 445   Theor. model
  2. 3sm9 A     437 a.a. 436   X-ray 2.26 Å
There are no PDB entries containing acamprosate bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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