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DB00622 : nicardipine

Approved drug nicardipine ... 15 targets DB00622

Generic name: nicardipine
 
Brand name(s): cardene, cardene iv, cardene sr.
Formula: C26H29N3O6
IUPAC Formula: 3-{2-[Benzyl(methyl)amino]ethyl} 5-Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-
Dicarboxylate

15
There are 15 target proteins defined in DrugBank for this drug.
 6 
6 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P11229 (ACM1_HUMAN)  -  Muscarinic acetylcholine receptor M1
UniProt id: P11229    460 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing nicardipine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing nicardipine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 4:   UniProt id: P08173 (ACM4_HUMAN)  -  Muscarinic acetylcholine receptor M4
UniProt id: P08173    479 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P08912 (ACM5_HUMAN)  -  Muscarinic acetylcholine receptor M5
UniProt id: P08912    532 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P62158 (CALM_HUMAN)  -  Calmodulin
UniProt id: P62158    148 a.a.  
1. 4djc A     151 a.a. 148   X-ray 1.35 Å
  2. 2jzi A     148 a.a. 148   NMR  
  3. 2k0e A     148 a.a. 148   NMR  
  4. 2kne A     148 a.a. 148   NMR  
  5. 2l53 A     148 a.a. 148   NMR  
   more ...
There are no PDB entries containing nicardipine bound to this target protein, although there are 88 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: Q13936 (CAC1C_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt id: Q13936    2220 a.a.  
1. 3g43 E     68 a.a. 66   X-ray 2.10 Å
  2. 3oxq E,F     64 a.a. 63   X-ray 2.55 Å
  3. 2be6 D     29 a.a. 29   X-ray 2.00 Å
  4. 2lqc B     24 a.a. 22   NMR  
  5. 2f3z B     18 a.a. 16   X-ray 1.60 Å
There are no PDB entries containing nicardipine bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 8:   UniProt id: Q08289 (CACB2_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-2
UniProt id: Q08289    660 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: Q01668 (CAC1D_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1D
UniProt id: Q01668    2161 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: P54289 (CA2D1_HUMAN)  -  Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt id: P54289    1103 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: P54750 (PDE1A_HUMAN)  -  Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
UniProt id: P54750    534 a.a.  
1lxq A     279 a.a. 279   Theor. model
There are no PDB entries containing nicardipine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 12:   UniProt id: Q01064 (PDE1B_HUMAN)  -  Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
UniProt id: Q01064    535 a.a.  
1. 4npv A     323 a.a. 323   X-ray 2.40 Å
  2. 4npw A     321 a.a. 321   X-ray 1.90 Å
  3. 1taz A     321 a.a. 320   X-ray 1.77 Å
  4. 1lxr A     304 a.a. 304   Theor. model
There are no PDB entries containing nicardipine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 13:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 14:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
UniProt id: P35368    520 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 15:   UniProt id: P25100 (ADA1D_HUMAN)  -  Alpha-1D adrenergic receptor
UniProt id: P25100    572 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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