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DB00598 : labetalol

Approved drug labetalol ... 4 targets DB00598

Generic name: labetalol
 
Brand name(s): albetol, ibidomide, normodyne, presdate, trandate.
Formula: C19H24N2O3
IUPAC Formula: 2-Hydroxy-5-{1-Hydroxy-2-[(4-Phenylbutan-2-Yl)amino]ethyl}benzamide

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P08588 (ADRB1_HUMAN)  -  Beta-1 adrenergic receptor
UniProt id: P08588    476 a.a.  
2lsq A     25 a.a. 19   NMR  
There are no PDB entries containing labetalol bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P07550 (ADRB2_HUMAN)  -  Beta-2 adrenergic receptor
UniProt id: P07550    412 a.a.  
1. 3pds A     442 a.a. 292   X-ray 3.50 Å
  2. 4gbr A     286 a.a. 283   X-ray 3.99 Å
  3. 3kj6 A     222 a.a. 222   X-ray 3.40 Å
  4. 2r4r A     216 a.a. 216   X-ray 3.40 Å
  5. 2r4s A     216 a.a. 216   X-ray 3.40 Å
   more ...
There are no PDB entries containing labetalol bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
UniProt id: P35368    520 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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