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DB00594 : amiloride

Approved drug amiloride ... 9 targets DB00594

Generic name: amiloride PDB Het Group: AMR
 
2 structures in PDB
Brand name(s): amipramidin, amipramizid, amipramizide, amiprazidine, guanamprazin, guanamprazine, midamor.
Formula: C6H8Cln7O
IUPAC Formula: 3,5-Diamino-6-Chloro-N-(Diaminomethylidene)pyrazine-2-Carboxamide
PDB name: 3,5-Diamino-N-(Aminoiminomethyl)-6-Chloropyrazinecarboxamide

9
There are 9 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P37088 (SCNNA_HUMAN)  -  Amiloride-sensitive sodium channel subunit alpha
UniProt id: P37088    668 a.a.  
2m3o P     11 a.a. 11   NMR  
There are no PDB entries containing amiloride bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P51168 (SCNNB_HUMAN)  -  Amiloride-sensitive sodium channel subunit beta
UniProt id: P51168    640 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P51170 (SCNNG_HUMAN)  -  Amiloride-sensitive sodium channel subunit gamma
UniProt id: P51170    649 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P51172 (SCNND_HUMAN)  -  Amiloride-sensitive sodium channel subunit delta
UniProt id: P51172    638 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P19801 (AOC1_HUMAN)  -  Amiloride-sensitive amine oxidase [copper-containing]
UniProt id: P19801    750 a.a.  
1. 3hi7 A,B     714 a.a. 711   X-ray 1.80 Å
  2. 3hig A,B     714 a.a. 711   X-ray 2.09 Å
  3. 3hii A,B     714 a.a. 711   X-ray 2.15 Å
  4. 3mph A,B     713 a.a. 710   X-ray 2.05 Å
  5. 3k5t A     711 a.a. 708   X-ray 2.11 Å
There are no PDB entries containing amiloride bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: Q16515 (ASIC2_HUMAN)  -  Amiloride-sensitive cation channel 1, neuronal
UniProt id: Q16515    512 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P78348 (ASIC1_HUMAN)  -  Amiloride-sensitive cation channel 2, neuronal
UniProt id: P78348    528 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P19634 (SL9A1_HUMAN)  -  Sodium/hydrogen exchanger 1
UniProt id: P19634    814 a.a.  
1. 2ygg A     66 a.a. 64   X-ray 2.23 Å
  2. 2mdf A     57 a.a. 49   NMR  
  3. 2e30 B     43 a.a. 43   NMR  
  4. 1y4e A     26 a.a. 26   NMR  
  5. 2kbv A     26 a.a. 26   NMR  
   more ...
There are no PDB entries containing amiloride bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 9:   UniProt id: P00749 (UROK_HUMAN)  -  Urokinase-type plasminogen activator
UniProt id: P00749    430 a.a.  
1f5l A   245 a.a. 244   X-ray 2.10 Å
The PDB contains 1 entry of amiloride bound to this target protein and 101 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with amiloride bound in the PDB

There is 1 "non-target" protein in the PDB containing the amiloride molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q1XA76 ()  -  Acid-sensing ion channel 1 OS=Gallus gallus GN=ASIC1 PE=1 SV=1
UniProt id: Q1XA76    526 a.a.  
4ntx A   410 a.a. 410   X-ray 2.27 Å
The PDB contains 1 entry of amiloride bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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