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DB00589 : lisuride

Approved drug lisuride ... 14 targets DB00589

Generic name: lisuride
 
Brand name(s): lisurida [inn-spanish], lisuride maleate, lisuride [inn], lisuridum [inn-latin], lysuride.
Formula: C20H26N4O
IUPAC Formula: 3,3-Diethyl-1-[(4s,7r)-6-Methyl-6,11-Diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-
1(16),2,9,12,14-Pentaen-4-Yl]urea

14
There are 14 target proteins defined in DrugBank for this drug.
 7 
7 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P28335 (5HT2C_HUMAN)  -  5-hydroxytryptamine 2C receptor
UniProt id: P28335    458 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P28222 (5HT1B_HUMAN)  -  5-hydroxytryptamine 1B receptor
UniProt id: P28222    389 a.a.  
2g1x A     390 a.a. 389   Theor. model
There are no PDB entries containing lisuride bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P08913 (ADA2A_HUMAN)  -  Alpha-2A adrenergic receptor
UniProt id: P08913    449 a.a.  
1. 1hll A     32 a.a. 32   NMR  
  2. 1hof A     32 a.a. 32   NMR  
  3. 1ho9 A     32 a.a. 31   NMR  
  4. 1hod A     32 a.a. 31   NMR  
There are no PDB entries containing lisuride bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P18089 (ADA2B_HUMAN)  -  Alpha-2B adrenergic receptor
UniProt id: P18089    449 a.a.  
2cva A     32 a.a. 32   Theor. model
There are no PDB entries containing lisuride bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 5:   UniProt id: P18825 (ADA2C_HUMAN)  -  Alpha-2C adrenergic receptor
UniProt id: P18825    462 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing lisuride bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: P35462 (DRD3_HUMAN)  -  D(3) dopamine receptor
UniProt id: P35462    400 a.a.  
   more ...
There are no PDB entries containing lisuride bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 8:   UniProt id: P21917 (DRD4_HUMAN)  -  D(4) dopamine receptor
UniProt id: P21917    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing lisuride bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 10:   UniProt id: P21918 (DRD5_HUMAN)  -  D(1B) dopamine receptor
UniProt id: P21918    477 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: P08908 (5HT1A_HUMAN)  -  5-hydroxytryptamine 1A receptor
UniProt id: P08908    422 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 12:   UniProt id: P28221 (5HT1D_HUMAN)  -  5-hydroxytryptamine 1D receptor
UniProt id: P28221    377 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 13:   UniProt id: P41595 (5HT2B_HUMAN)  -  5-hydroxytryptamine 2B receptor
UniProt id: P41595    481 a.a.  
   more ...
There are no PDB entries containing lisuride bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 14:   UniProt id: P28223 (5HT2A_HUMAN)  -  5-hydroxytryptamine 2A receptor
UniProt id: P28223    471 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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