DB00575 : clonidine

Approved drug clonidine ... 3 targets DB00575

Generic name: clonidine PDB Het Group: CLU
1 structure in PDB
Brand name(s): adesipress, catapres, catapres-tts, catapresan, catapressan, catarpres, catarpresan, clonistada, dixarit, duraclon, duraclont, ipotensium, isoglaucon, tenso-timelets.
Formula: C9H9Cl2N3
IUPAC Formula: N-(2,6-Dichlorophenyl)-4,5-Dihydro-1h-Imidazol-2-Amine
PDB name: 2,6-Dichloro-N-Imidazolidin-2-Ylideneaniline

There are 3 target proteins defined in DrugBank for this drug.
2 of these target proteins have one or more structures in the PDB.
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
KEGG drug
Ligand Expo


Target proteins

DrugBank drug Target 1:   UniProt id: P08913 (ADA2A_HUMAN)  -  Alpha-2A adrenergic receptor
UniProt id: P08913    449 a.a.  
1. 1hll A     32 a.a. 32   NMR  
  2. 1hof A     32 a.a. 32   NMR  
  3. 1ho9 A     32 a.a. 31   NMR  
  4. 1hod A     32 a.a. 31   NMR  
There are no PDB entries containing clonidine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P18089 (ADA2B_HUMAN)  -  Alpha-2B adrenergic receptor
UniProt id: P18089    449 a.a.  
2cva A     32 a.a. 32   Theor. model
There are no PDB entries containing clonidine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P18825 (ADA2C_HUMAN)  -  Alpha-2C adrenergic receptor
  No Pfam domain assignments available for this protein.
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule


Other proteins with clonidine bound in the PDB

There is 1 "non-target" protein in the PDB containing the clonidine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q29437 ()  -  Primary amine oxidase, liver isozyme OS=Bos taurus PE=1 SV=1
UniProt id: Q29437    761 a.a.  
2pnc A,B   622 a.a. 621   X-ray 2.40 Å
The PDB contains 1 entry of clonidine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.


Structure selection

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