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DB00573 : fenoprofen

Approved drug fenoprofen ... 2 targets DB00573

Generic name: fenoprofen PDB Het Group: PFN
 
2 structures in PDB
Brand name(s): nalfon.
Formula: C15H14O3
IUPAC Formula: 2-(3-Phenoxyphenyl)propanoic acid
PDB name: Fenoprofen

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35354 (PGH2_HUMAN)  -  Prostaglandin G/H synthase 2
UniProt id: P35354    603 a.a.  
1v0x A     604 a.a. 603   Theor. model
There are no PDB entries containing fenoprofen bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P23219 (PGH1_HUMAN)  -  Prostaglandin G/H synthase 1
UniProt id: P23219    599 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with fenoprofen bound in the PDB

There are 2 "non-target" proteins in the PDB containing the fenoprofen molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P24627 ()  -  Lactotransferrin OS=Bos taurus GN=LTF PE=1 SV=2
UniProt id: P24627    707 a.a.  
4ned A   341 a.a. 339   X-ray 2.10 Å
The PDB contains 1 entry of fenoprofen bound to this protein
Protein 2:   UniProt id: Q8N4Q0 ()  -  Zinc-binding alcohol dehydrogenase domain-containing protein 2 OS=Homo sapiens GN=ZADH2 PE=1 SV=1
UniProt id: Q8N4Q0    376 a.a.  
2x7h A,B   343 a.a. 343   X-ray 1.60 Å
The PDB contains 1 entry of fenoprofen bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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