spacer
spacer

Search 

DB00570 : vinblastine

Approved drug vinblastine ... 6 targets DB00570

Generic name: vinblastine PDB Het Group: VLB
 
2 structures in PDB
Brand name(s): nincaluicolflastine, rozevin, velban, velbe, vinblastin, vinblastina [dcit], vinblastine sulfate, vinblastinum [inn-latin], vincaleucoblastin, vincaleucoblastine, vincaleukoblastine, vincoblastine.
Formula: C46H58N4O9
IUPAC Formula: Methyl (1r,9r,10s,11r,12r,19r)-11-(Acetyloxy)-12-Ethyl-4-[(13s,15s,17s)-17-Ethyl-17-Hydroxy-13-
(Methoxycarbonyl)-1,11-Diazatetracyclo[13.3.1.0^{4,12}.0^{5,10}]nonadeca-4(12),5,7,9-Tetraen-13-Yl]-
10-Hydroxy-5-Methoxy-8-Methyl-8,16-Diazapentacyclo[10.6.1.0^{1,9}.0^{2,7}.0^{16,19}]nonadeca-
2(7),3,5,13-Tetraene-10-Carboxylate
PDB name: (2alpha,2'Beta,3beta,4alpha,5beta)-Vincaleukoblastine

6
There are 6 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
RxList
ChEBI
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: Q71U36 (TBA1A_HUMAN)  -  Tubulin alpha-3 chain
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P07437 (TBB5_HUMAN)  -  Tubulin beta chain
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q9UJT1 (TBD_HUMAN)  -  Tubulin delta chain
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P23258 (TBG1_HUMAN)  -  Tubulin gamma-1 chain
UniProt id: P23258    450 a.a.  
1. 3cb2 A,B     432 a.a. 430   X-ray 2.30 Å
  2. 1z5v A     412 a.a. 410   X-ray 2.71 Å
  3. 1z5w A     409 a.a. 407   X-ray 3.00 Å
There are no PDB entries containing vinblastine bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: Q9UJT0 (TBE_HUMAN)  -  Tubulin epsilon chain
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P05412 (JUN_HUMAN)  -  Transcription factor AP-1
UniProt id: P05412    330 a.a.  
1. 1t2k C     62 a.a. 60   X-ray 3.00 Å
  2. 1fos F     57 a.a. 56   X-ray 3.05 Å
  3. 1jnm A,B     56 a.a. 55   X-ray 2.20 Å
  4. 1s9k E     52 a.a. 52   X-ray 3.10 Å
  5. 1a02 J     52 a.a. 51   X-ray 2.70 Å
There are no PDB entries containing vinblastine bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with vinblastine bound in the PDB

There are 2 "non-target" proteins in the PDB containing the vinblastine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: D0VWY9 ()  -  Tubulin beta chain OS=Ovis aries PE=1 SV=1
UniProt id: D0VWY9    444 a.a.  
4eb6 B,D   432 a.a. 427   X-ray 3.47 Å
The PDB contains 1 entry of vinblastine bound to this protein
Protein 2:   UniProt id: Q6B856 ()  -  Tubulin beta-2B chain OS=Bos taurus GN=TUBB2B PE=1 SV=2
UniProt id: Q6B856    444 a.a.  
1z2b B,D   419 a.a. 416   X-ray 4.10 Å
The PDB contains 1 entry of vinblastine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer