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DB00558 : zanamivir

Approved drug zanamivir ... 3 targets DB00558

Generic name: zanamivir PDB Het Group: ZMR
 
19 structures in PDB
Brand name(s): relenza.
Formula: C12H20N4O7
IUPAC Formula: (2r,3r,4s)-4-[(Diaminomethylidene)amino]-3-Acetamido-2-[(1r,2r)-1,2,3-Trihydroxypropyl]-3,4-Dihydro-
2h-Pyran-6-Carboxylic acid
PDB name: Zanamivir

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures of the drug molecule bound to its target protein.
 17 
There are 17 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Information  
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Target proteins

DrugBank drug Target 1:   UniProt id: P06818 (NRAM_I79A0)  -  Neuraminidase
UniProt id: P06818    469 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P27907 (NRAM_INBBE)  -  Neuraminidase
UniProt id: P27907    464 a.a.  
1a4g A,B   390 a.a. 390   X-ray 2.20 Å
The PDB contains 1 entry of zanamivir bound to this target protein and 5 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 3:   UniProt id: Q9Y3R4 (NEUR2_HUMAN)  -  Sialidase-2
UniProt id: Q9Y3R4    379 a.a.  
2f0z A   356 a.a. 355   X-ray 2.80 Å
The PDB contains 1 entry of zanamivir bound to this target protein and 16 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with zanamivir bound in the PDB

There are 17 "non-target" proteins in the PDB containing the zanamivir molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above. Only 10 of the 17 proteins are listed below.

Protein 1:   UniProt id: A1ILL9 ()  -  Neuraminidase OS=Influenza A virus (strain A/Duck/Alberta/60/1976 H12N5) GN=NA PE=1 SV=1
UniProt id: A1ILL9    472 a.a.  
3san A,B   394 a.a. 394   X-ray 1.60 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 2:   UniProt id: A9YN63 ()  -  Neuraminidase OS=Influenza A virus (A/swine/Missouri/2124514/2006(H2N3)) GN=NA PE=1 SV=1
UniProt id: A9YN63    468 a.a.  
4i00 A   388 a.a. 386   X-ray 1.60 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 3:   UniProt id: C0LT34 ()  -  Neuraminidase OS=Influenza B virus (B/Brisbane/60/2008) GN=NA PE=1 SV=1
UniProt id: C0LT34    465 a.a.  
4cpn A,B   390 a.a. 390   X-ray 2.40 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 4:   UniProt id: C3W5S3 ()  -  Neuraminidase OS=Influenza A virus (strain swl A/California/04/2009 H1N1) GN=NA PE=1 SV=1
UniProt id: C3W5S3    468 a.a.  
3ti5 A,B   387 a.a. 387   X-ray 1.90 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 5:   UniProt id: C7FH46 ()  -  Neuraminidase OS=Influenza A virus (A/California/07/2009(H1N1)) GN=NA PE=1 SV=1
UniProt id: C7FH46    468 a.a.  
4b7q A,B,C,D   387 a.a. 386   X-ray 2.73 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 6:   UniProt id: F8UU09 ()  -  Neuraminidase OS=Influenza A virus (A/Netherlands/2631_1202/2010(H1N1)) GN=NA PE=1 SV=1
UniProt id: F8UU09    468 a.a.  
4b7n A   386 a.a. 386   X-ray 2.84 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 7:   UniProt id: P03472 ()  -  Neuraminidase OS=Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9) GN=NA PE=1 SV=1
UniProt id: P03472    469 a.a.  
1nnc A   388 a.a. 388   X-ray 1.80 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 8:   UniProt id: P62575 ()  -  Sialidase A OS=Streptococcus pneumoniae GN=nanA PE=1 SV=1
UniProt id: P62575    1034 a.a.  
2ya7 A,B,C,D   469 a.a. 464   X-ray 1.89 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 9:   UniProt id: Q07599 ()  -  Neuraminidase OS=Influenza A virus (strain A/Duck/Ukraine/1/1963 H3N8) GN=NA PE=1 SV=1
UniProt id: Q07599    469 a.a.  
2htq A   387 a.a. 387   X-ray 2.20 Å
The PDB contains 1 entry of zanamivir bound to this protein
Protein 10:   UniProt id: Q194T1 ()  -  Neuraminidase OS=Influenza A virus (A/RI/5+/1957(H2N2)) PE=1 SV=1
UniProt id: Q194T1    468 a.a.  
3tic A,B,C,D   388 a.a. 388   X-ray 1.89 Å
The PDB contains 1 entry of zanamivir bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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