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DB00552 : pentostatin

Approved drug pentostatin ... 1 target DB00552

Generic name: pentostatin PDB Het Group: DCF
 
2 structures in PDB
Brand name(s): co-v, co-vidarabine, covidarabine, nipent, pd-adi, vidarbine, vira a deaminase inhibitor.
Formula: C11H16N4O4
IUPAC Formula: (8r)-3-[(2r,4s,5r)-4-Hydroxy-5-(Hydroxymethyl)oxolan-2-Yl]-3h,6h,7h,8h-Imidazo[4,5-D][1,3]diazepin-
8-Ol
PDB name: 2'-Deoxycoformycin

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P00813 (ADA_HUMAN)  -  Adenosine deaminase
UniProt id: P00813    362 a.a.  
1. 1m7m A     363 a.a. 362   Theor. model
  2. 3iar A     360 a.a. 359   X-ray 1.52 Å
There are no PDB entries containing pentostatin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with pentostatin bound in the PDB

There are 2 "non-target" proteins in the PDB containing the pentostatin molecule bound. That is, the UniProt code for the proteins is missing or does not match the drug target above.

Protein 1:   UniProt id: A5KE01 ()  -  Adenosine deaminase, putative OS=Plasmodium vivax (strain Salvador I) GN=PVX_111245 PE=1 SV=1
UniProt id: A5KE01    362 a.a.  
2pgr A   359 a.a. 359   X-ray 2.30 Å
The PDB contains 1 entry of pentostatin bound to this protein
Protein 2:   UniProt id: P03958 ()  -  Adenosine deaminase OS=Mus musculus GN=Ada PE=1 SV=3
UniProt id: P03958    351 a.a.  
1a4l A,B,C,D   349 a.a. 349   X-ray 2.60 Å
The PDB contains 1 entry of pentostatin bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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