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DB00544 : fluorouracil

Approved drug fluorouracil ... 3 targets DB00544

Generic name: fluorouracil PDB Het Group: URF
 
10 structures in PDB
Brand name(s): adrucil, arumel, carac, carzonal, effluderm, efudex, efudix, efurix, fluoroblastin, fluoroplex, fluracilum, fluri, fluril, ftoruracil, kecimeton, phthoruracil, phtoruracil, queroplex, timazin, urf, ulup.
Formula: C4H3Fn2O2
IUPAC Formula: 5-Fluoro-1,2,3,4-Tetrahydropyrimidine-2,4-Dione
PDB name: 5-Fluorouracil

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 9 
There are 9 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
Links  
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KEGG drug
PubChem
MSDChem
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Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P04818 (TYSY_HUMAN)  -  Thymidylate synthase
UniProt id: P04818    312 a.a.  
1. 1hvy A,B,C,D     287 a.a. 286   X-ray 1.90 Å
  2. 1ju6 A,B,C,D     286 a.a. 285   X-ray 2.89 Å
  3. 1juj A,B,C,D     286 a.a. 285   X-ray 3.00 Å
  4. 3gg5 A,B,C,D     283 a.a. 283   X-ray 2.77 Å
  5. 3ejl A,B,C,D     283 a.a. 283   X-ray 3.20 Å
   more ...
There are no PDB entries containing fluorouracil bound to this target protein, although there are 36 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with fluorouracil bound in the PDB

There are 9 "non-target" proteins in the PDB containing the fluorouracil molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: A5PJH9 ()  -  Uridine phosphorylase OS=Bos taurus GN=UPP1 PE=1 SV=1
UniProt id: A5PJH9    308 a.a.  
3kvr A,B   293 a.a. 293   X-ray 2.60 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 2:   UniProt id: D9J2T9 ()  -  Ribosome inactivating protein (Fragment) OS=Momordica balsamina GN=RIP PE=1 SV=1
UniProt id: D9J2T9    245 a.a.  
4o0o A   246 a.a. 245   X-ray 2.59 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 3:   UniProt id: P0A1F6 ()  -  Uridine phosphorylase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=udp PE=1 SV=2
UniProt id: P0A1F6    252 a.a.  
4e1v A,E,F,D,...   248 a.a. 248   X-ray 2.15 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 4:   UniProt id: P12758 ()  -  Uridine phosphorylase OS=Escherichia coli (strain K12) GN=udp PE=1 SV=3
UniProt id: P12758    252 a.a.  
3kvv A,B,C,D,...   243 a.a. 243   X-ray 1.80 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 5:   UniProt id: Q16831 ()  -  Uridine phosphorylase 1 OS=Homo sapiens GN=UPP1 PE=1 SV=1
UniProt id: Q16831    309 a.a.  
3nbq A,B,C,D   293 a.a. 293   X-ray 2.30 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 6:   UniProt id: Q26998 ()  -  Uracil phosphoribosyltransferase OS=Toxoplasma gondii GN=uprt PE=1 SV=1
UniProt id: Q26998    243 a.a.  
1upf D,C,B,A   224 a.a. 221   X-ray 2.30 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 7:   UniProt id: Q28943 ()  -  Dihydropyrimidine dehydrogenase [NADP(+)] OS=Sus scrofa GN=DPYD PE=1 SV=1
UniProt id: Q28943    1024 a.a.  
1h7x A,B,C,D   1016 a.a. 1014   X-ray 2.01 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 8:   UniProt id: Q5PKP6 ()  -  Uridine phosphorylase OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) GN=udp PE=1 SV=1
UniProt id: Q5PKP6    252 a.a.  
3nsr A,B,C,D,...   249 a.a. 249   X-ray 2.20 Å
The PDB contains 1 entry of fluorouracil bound to this protein
Protein 9:   UniProt id: Q80J95 ()  -  Polyprotein OS=Murine norovirus 1 PE=1 SV=2
UniProt id: Q80J95    1684 a.a.  
3nai A,B,C   486 a.a. 486   X-ray 2.56 Å
The PDB contains 1 entry of fluorouracil bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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