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DB00540 : nortriptyline

Approved drug nortriptyline ... 12 targets DB00540

Generic name: nortriptyline PDB Het Group: 21B
 
1 structure in PDB
Brand name(s): aventyl hcl, acetexa, allegron, altilev, amitryptyline, demethyl-, ateben, avantyl, demethylamitriptylene, demethylamitriptyline, demethylamitryptyline, desitriptilina, desmethylamitriptyline, lumbeck, noramitriptyline, noritren, nortrilen, nortriptyline hcl, nortryptiline, norzepine, pamelor, psychostyl, sensaval, sensival ventyl, sesaval, vividyl.
Formula: C19H21N
IUPAC Formula: Methyl({3-[(2e)-Tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-Hexaen-2-Ylidene]propyl})amine
PDB name: Nortriptyline

12
There are 12 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing nortriptyline bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P08173 (ACM4_HUMAN)  -  Muscarinic acetylcholine receptor M4
UniProt id: P08173    479 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P08912 (ACM5_HUMAN)  -  Muscarinic acetylcholine receptor M5
UniProt id: P08912    532 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P23975 (SC6A2_HUMAN)  -  Sodium-dependent noradrenaline transporter
UniProt id: P23975    617 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P31645 (SC6A4_HUMAN)  -  Sodium-dependent serotonin transporter
UniProt id: P31645    630 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P28223 (5HT2A_HUMAN)  -  5-hydroxytryptamine 2A receptor
UniProt id: P28223    471 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P08908 (5HT1A_HUMAN)  -  5-hydroxytryptamine 1A receptor
UniProt id: P08908    422 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing nortriptyline bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 9:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: P25100 (ADA1D_HUMAN)  -  Alpha-1D adrenergic receptor
UniProt id: P25100    572 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: P11229 (ACM1_HUMAN)  -  Muscarinic acetylcholine receptor M1
UniProt id: P11229    460 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 12:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing nortriptyline bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with nortriptyline bound in the PDB

There is 1 "non-target" protein in the PDB containing the nortriptyline molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q7K4Y6 ()  -  Transporter OS=Drosophila melanogaster GN=DAT PE=1 SV=1
UniProt id: Q7K4Y6    630 a.a.  
4m48 A   532 a.a. 527   X-ray 2.96 Å
The PDB contains 1 entry of nortriptyline bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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