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DB00529 : foscarnet

Approved drug foscarnet ... 2 targets DB00529

Generic name: foscarnet PDB Het Group: PPF
 
6 structures in PDB
Brand name(s): foscarmet, foscavir, triapten.
Formula: Ch3O5P
IUPAC Formula: Phosphonoformic acid
PDB name: Phosphonoformic acid

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 5 
There are 5 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P08546 (DPOL_HCMVA)  -  DNA polymerase
UniProt id: P08546    1241 a.a.  
1yyp B     20 a.a. 20   X-ray 2.50 Å
There are no PDB entries containing foscarnet bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P04293 (DPOL_HHV11)  -  DNA polymerase
UniProt id: P04293    1235 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with foscarnet bound in the PDB

There are 5 "non-target" proteins in the PDB containing the foscarnet molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P07379 ()  -  Phosphoenolpyruvate carboxykinase, cytosolic [GTP] OS=Rattus norvegicus GN=Pck1 PE=1 SV=1
UniProt id: P07379    621 a.a.  
2rk8 A,B   622 a.a. 621   X-ray 2.00 Å
The PDB contains 1 entry of foscarnet bound to this protein
Protein 2:   UniProt id: Q38087 ()  -  DNA polymerase OS=Enterobacteria phage RB69 GN=43 PE=1 SV=1
UniProt id: Q38087    902 a.a.  
3kd5 E   905 a.a. 892   X-ray 2.69 Å
The PDB contains 1 entry of foscarnet bound to this protein
Protein 3:   UniProt id: Q51782 ()  -  Phosphonoacetate hydrolase OS=Pseudomonas fluorescens GN=phnA PE=1 SV=1
UniProt id: Q51782    406 a.a.  
1ei6 A,B,C,D   404 a.a. 403   X-ray 2.10 Å
The PDB contains 1 entry of foscarnet bound to this protein
Protein 4:   UniProt id: Q92UV8 ()  -  Probable phosphonoacetate hydrolase OS=Rhizobium meliloti (strain 1021) GN=phnA PE=1 SV=1
UniProt id: Q92UV8    423 a.a.  
3t01 A   413 a.a. 413   X-ray 1.60 Å
The PDB contains 1 entry of foscarnet bound to this protein
Protein 5:   UniProt id: Q9I4K6 ()  -  Glutathione transferase FosA OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=fosA PE=1 SV=1
UniProt id: Q9I4K6    134 a.a.  
1nki A,B   134 a.a. 133   X-ray
The PDB contains 1 entry of foscarnet bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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