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DB00523 : alitretinoin

Approved drug alitretinoin ... 6 targets DB00523

Generic name: alitretinoin PDB Het Group: 9CR
 
3 structures in PDB
Brand name(s): panretin, panretin gel, panretyn, panrexin, renova, retin-a, retin-a micro, vesanoid.
Formula: C20H28O2
IUPAC Formula: (2e,4e,6z,8e)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-Yl)nona-2,4,6,8-Tetraenoic acid
PDB name: (9cis)-Retinoic acid

6
There are 6 target proteins defined in DrugBank for this drug.
 6 
6 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: P10276 (RARA_HUMAN)  -  Retinoic acid receptor alpha
UniProt id: P10276    461 a.a.  
1. 3a9e B     239 a.a. 239   X-ray 2.75 Å
  2. 3kmr A     234 a.a. 234   X-ray 1.80 Å
  3. 4dqm A,C     234 a.a. 234   X-ray 2.75 Å
  4. 1dkf B     232 a.a. 232   X-ray 2.50 Å
  5. 3kmz B,A     221 a.a. 221   X-ray 2.10 Å
There are no PDB entries containing alitretinoin bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P19793 (RXRA_HUMAN)  -  Retinoic acid receptor RXR-alpha
UniProt id: P19793    461 a.a.  
1fm9 A   232 a.a. 232   X-ray 2.10 Å
The PDB contains 1 entry of alitretinoin bound to this target protein and 56 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 3:   UniProt id: P10826 (RARB_HUMAN)  -  Retinoic acid receptor beta
UniProt id: P10826    454 a.a.  
1. 4dm6 A,B     240 a.a. 240   X-ray 1.90 Å
  2. 4jyi A,B     239 a.a. 238   X-ray 1.90 Å
  3. 4dm8 A,B     238 a.a. 238   X-ray 2.30 Å
  4. 4jyg A,B     239 a.a. 238   X-ray 2.35 Å
  5. 4jyh A,B     239 a.a. 238   X-ray 2.60 Å
   more ...
There are no PDB entries containing alitretinoin bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P28702 (RXRB_HUMAN)  -  Retinoic acid receptor RXR-beta
UniProt id: P28702    532 a.a.  
1. 1uhl A     214 a.a. 214   X-ray 2.90 Å
  2. 1h9u A,B,C,D     201 a.a. 201   X-ray 2.70 Å
There are no PDB entries containing alitretinoin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P13631 (RARG_HUMAN)  -  Retinoic acid receptor gamma-1
UniProt id: P13631    453 a.a.  
1. 2lbd A     238 a.a. 238   X-ray 2.06 Å
  2. 3lbd A     237 a.a. 237   X-ray 2.40 Å
  3. 4lbd A     237 a.a. 237   X-ray 2.50 Å
  4. 1exa A     236 a.a. 236   X-ray 1.59 Å
  5. 1exx A     236 a.a. 236   X-ray 1.67 Å
   more ...
There are no PDB entries containing alitretinoin bound to this target protein, although there are 9 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P48443 (RXRG_HUMAN)  -  Retinoic acid receptor RXR-gamma
UniProt id: P48443    462 a.a.  
2gl8 A,B,C,D     190 a.a. 190   X-ray 2.40 Å
There are no PDB entries containing alitretinoin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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