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DB00509 : dextrothyroxine

Approved drug dextrothyroxine ... 3 targets DB00509

Generic name: dextrothyroxine
 
Brand name(s): choloxin, dynothel, eulipos, lisolipin.
Formula: C15H11I4No4
IUPAC Formula: (2r)-2-Amino-3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3,5-Diiodophenyl]propanoic acid

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P10827 (THA_HUMAN)  -  Thyroid hormone receptor alpha
UniProt id: P10827    489 a.a.  
1. 3ilz A     263 a.a. 222   X-ray 1.85 Å
  2. 2h79 A     262 a.a. 222   X-ray 1.87 Å
  3. 4lnw A     259 a.a. 222   X-ray 1.90 Å
  4. 3jzb A     260 a.a. 222   X-ray 2.01 Å
  5. 4lnx A     259 a.a. 222   X-ray 2.05 Å
   more ...
There are no PDB entries containing dextrothyroxine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P10828 (THB_HUMAN)  -  Thyroid hormone receptor beta-1
UniProt id: P10828    460 a.a.  
1. 2j4a A     251 a.a. 250   X-ray 2.20 Å
  2. 1nax A     250 a.a. 250   X-ray 2.70 Å
  3. 1nq0 A     253 a.a. 249   X-ray 2.40 Å
  4. 1nq2 A     255 a.a. 249   X-ray 2.40 Å
  5. 1n46 A,B     248 a.a. 248   X-ray 2.20 Å
   more ...
There are no PDB entries containing dextrothyroxine bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P07202 (PERT_HUMAN)  -  Thyroid peroxidase
UniProt id: P07202    933 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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