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DB00483 : gallamine triethiodide

Approved drug gallamine triethiodide ... 3 targets DB00483

Generic name: gallamine triethiodide
 
Brand name(s): flaxedil, fourneau 2559, gallaflex, miowas g, parexyl, pirolakson, pyrolaxon, relaxan, remyolan, retensin, sincurarine, syncurarine, tricuran.
Formula: C30H60I3N3O3
IUPAC Formula: (2-{2,3-Bis[2-(Triethylazaniumyl)ethoxy]phenoxy}ethyl)triethylazanium triiodide

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing gallamine triethiodide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P22303 (ACES_HUMAN)  -  Acetylcholinesterase
UniProt id: P22303    613 a.a.  
1. 4bdt A     563 a.a. 563   X-ray 3.10 Å
  2. 1clj       538 a.a. 538   Theor. model
  3. 1puv A     538 a.a. 538   Theor. model
  4. 1puw A     538 a.a. 538   Theor. model
  5. 2x8b A     536 a.a. 535   X-ray 2.95 Å
   more ...
There are no PDB entries containing gallamine triethiodide bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q15822 (ACHA2_HUMAN)  -  Neuronal acetylcholine receptor subunit alpha-2
UniProt id: Q15822    529 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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