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DB00461 : nabumetone

Approved drug nabumetone ... 2 targets DB00461

Generic name: nabumetone PDB Het Group: NBO
 
1 structure in PDB
Brand name(s): arthaxan, balmox, consolan, dolsinal, flambate, listran, mebutan, nabuser, prodac, relafen, relif, relifen, relifex, unimetone.
Formula: C15H16O2
IUPAC Formula: 4-(6-Methoxynaphthalen-2-Yl)butan-2-One
PDB name: Nabumetone

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35354 (PGH2_HUMAN)  -  Prostaglandin G/H synthase 2
UniProt id: P35354    603 a.a.  
1v0x A     604 a.a. 603   Theor. model
There are no PDB entries containing nabumetone bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P23219 (PGH1_HUMAN)  -  Prostaglandin G/H synthase 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with nabumetone bound in the PDB

There is 1 "non-target" protein in the PDB containing the nabumetone molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P24627 ()  -  Lactotransferrin OS=Bos taurus GN=LTF PE=1 SV=2
UniProt id: P24627    707 a.a.  
3taj A   341 a.a. 339   X-ray 1.70 Å
The PDB contains 1 entry of nabumetone bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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