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DB00456 : cefalotin

Approved drug cefalotin ... 8 targets DB00456

Generic name: cefalotin PDB Het Group: CLS
 
3 structures in PDB
Brand name(s): averon-1, cemastin, coaxin, keflin, seffin.
Formula: C16H16N2O6S2
IUPAC Formula: (6r,7r)-3-[(Acetyloxy)methyl]-8-Oxo-7-[2-(Thiophen-2-Yl)acetamido]-5-Thia-1-Azabicyclo[4.2.0]oct-2-
Ene-2-Carboxylic acid
PDB name: Cephalothin

8
There are 8 target proteins defined in DrugBank for this drug.
 5 
5 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P15555 (DAC_STRSR)  -  D-alanyl-D-alanine carboxypeptidase
UniProt id: P15555    405 a.a.  
1. 3pte A     347 a.a. 347   X-ray 1.60 Å
  2. 1ceg A     347 a.a. 347   X-ray 1.80 Å
  3. 1cef A     347 a.a. 347   X-ray 2.04 Å
  4. 1hvb A     346 a.a. 346   X-ray 1.17 Å
  5. 1yqs A     345 a.a. 345   X-ray 1.05 Å
   more ...
There are no PDB entries containing cefalotin bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q8DR59 (PBPA_STRR6)  -  Penicillin-binding protein 1A
UniProt id: Q8DR59    718 a.a.  
1. 2c5w A     16 a.a. 16   X-ray 2.55 Å
  2. 2c6w A     16 a.a. 16   X-ray 2.61 Å
There are no PDB entries containing cefalotin bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q7CRA4 (Q7CRA4_STRR6)  -  Penicillin-binding protein 1b
UniProt id: Q7CRA4    820 a.a.  
1. 2y2m A     471 a.a. 457   X-ray 1.62 Å
  2. 2y2o A     471 a.a. 457   X-ray 1.88 Å
  3. 2y2j A     470 a.a. 456   X-ray 2.06 Å
  4. 2xd5 A,B     469 a.a. 456   X-ray 2.50 Å
  5. 2y2k A     469 a.a. 455   X-ray 2.09 Å
   more ...
There are no PDB entries containing cefalotin bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q75Y35 (Q75Y35_STREE)  -  Penicillin-binding protein 3
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q8DNB6 (Q8DNB6_STRR6)  -  Penicillin-binding protein 2a
UniProt id: Q8DNB6    731 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P0A3M6 (PBP2_STRR6)  -  Penicillin-binding protein 2B
UniProt id: P0A3M6    679 a.a.  
2waf A     619 a.a. 617   X-ray 3.29 Å
There are no PDB entries containing cefalotin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: Q8XJ01 (PBPA_CLOPE)  -  Penicillin-binding proteins 1A/1B
UniProt id: Q8XJ01    679 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P00811 (AMPC_ECOLI)  -  Beta-lactamase
UniProt id: P00811    376 a.a.  
1kvl A,B   358 a.a. 357   X-ray 1.53 Å
The PDB contains 1 entry of cefalotin bound to this target protein and 92 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with cefalotin bound in the PDB

There are 2 "non-target" proteins in the PDB containing the cefalotin molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q47066 ()  -  Beta-lactamase Toho-1 OS=Escherichia coli GN=bla PE=1 SV=1
UniProt id: Q47066    290 a.a.  
2zq9 A   259 a.a. 256   X-ray 1.07 Å
The PDB contains 1 entry of cefalotin bound to this protein
Protein 2:   UniProt id: Q9HV14 ()  -  Uncharacterized protein OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=PA4794 PE=1 SV=1
UniProt id: Q9HV14    159 a.a.  
4kox A   159 a.a. 158   X-ray 1.80 Å
The PDB contains 1 entry of cefalotin bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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