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DB00449 : dipivefrin

Approved drug dipivefrin ... 4 targets DB00449

Generic name: dipivefrin
 
Brand name(s): akpro, dipivefrin hcl, dipivefrin [usan], dipivefrina [inn-spanish], dipivefrine, dipivefrinum [inn-latin], ophtho-dipivefrin, propine, propine c cap b.i.d..
Formula: C19H29No5
IUPAC Formula: 2-[(2,2-Dimethylpropanoyl)oxy]-5-[1-Hydroxy-2-(Methylamino)ethyl]phenyl 2,2-Dimethylpropanoate

4
There are 4 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P08913 (ADA2A_HUMAN)  -  Alpha-2A adrenergic receptor
UniProt id: P08913    449 a.a.  
1. 1hll A     32 a.a. 32   NMR  
  2. 1hof A     32 a.a. 32   NMR  
  3. 1ho9 A     32 a.a. 31   NMR  
  4. 1hod A     32 a.a. 31   NMR  
There are no PDB entries containing dipivefrin bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P07550 (ADRB2_HUMAN)  -  Beta-2 adrenergic receptor
UniProt id: P07550    412 a.a.  
1. 3pds A     442 a.a. 292   X-ray 3.50 Å
  2. 4gbr A     286 a.a. 283   X-ray 3.99 Å
  3. 3kj6 A     222 a.a. 222   X-ray 3.40 Å
  4. 2r4r A     216 a.a. 216   X-ray 3.40 Å
  5. 2r4s A     216 a.a. 216   X-ray 3.40 Å
   more ...
There are no PDB entries containing dipivefrin bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P06276 (CHLE_HUMAN)  -  Cholinesterase
UniProt id: P06276    601 a.a.  
1. 3o9m A,B     531 a.a. 531   X-ray 2.98 Å
  2. 4tpk A,B     528 a.a. 528   X-ray 2.70 Å
  3. 4aqd A,B     527 a.a. 527   X-ray 2.50 Å
  4. 2pm8 A,B     530 a.a. 527   X-ray 2.80 Å
  5. 2wij A     527 a.a. 524   X-ray 2.10 Å
   more ...
There are no PDB entries containing dipivefrin bound to this target protein, although there are 39 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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