spacer
spacer

Search 

DB00436 : bendroflumethiazide

Approved drug bendroflumethiazide ... 5 targets DB00436

Generic name: bendroflumethiazide
 
Brand name(s): aprinox, bentride, benuron, benzy-rodiuran, benzylrodiuran, berkozide, bristuric, bristuron, centyl, corzide, ft 8, flumersil, flumesil, intolex, livesan, naigaril, nateretin, naturetin, naturetin-2.5, naturine, neo-naclex, neo-rontyl, niagaril, nikion, orsile, pluryl, pluryle, plusuril, poliuron, rautrax n, rauzide, relan beta, repicin, salural, salures, sinesalin, sodiuretic, thiazidico, urlea.
Formula: C15H14F3N3O4S2
IUPAC Formula: 3-Benzyl-1,1-Dioxo-6-(Trifluoromethyl)-3,4-Dihydro-2h-1l^{6},2,4-Benzothiadiazine-7-Sulfonamide

5
There are 5 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
ChEBI
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P55017 (S12A3_HUMAN)  -  Solute carrier family 12 member 3
UniProt id: P55017    1021 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: Q12791 (KCMA1_HUMAN)  -  Calcium-activated potassium channel subunit alpha 1
UniProt id: Q12791    1235 a.a.  
1. 3naf A     632 a.a. 616   X-ray 3.10 Å
  2. 3mt5 A     593 a.a. 593   X-ray 3.00 Å
  3. 2k44 A     28 a.a. 28   NMR  
There are no PDB entries containing bendroflumethiazide bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing bendroflumethiazide bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 1lug A     259 a.a. 259   X-ray
  2. 2qo8 A     259 a.a. 259   X-ray 1.40 Å
  3. 3igp A     259 a.a. 259   X-ray 1.65 Å
  4. 3sbh A     259 a.a. 259   X-ray 1.65 Å
  5. 1can A     259 a.a. 259   X-ray 1.90 Å
   more ...
There are no PDB entries containing bendroflumethiazide bound to this target protein, although there are 479 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
1. 1znc A     262 a.a. 262   X-ray 2.80 Å
  2. 3f7b A,B     257 a.a. 257   X-ray 2.05 Å
  3. 3fw3 A,B     249 a.a. 249   X-ray 1.72 Å
  4. 3f7u A,B,C,D     247 a.a. 247   X-ray 2.00 Å
There are no PDB entries containing bendroflumethiazide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer

  spacer

spacer