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DB00433 : prochlorperazine

Approved drug prochlorperazine ... 1 target DB00433

Generic name: prochlorperazine PDB Het Group: P77
 
1 structure in PDB
Brand name(s): bayer a 173, buccastem, capazine, combid, compazine, compro, emelent, emetiral, eskatrol, kronocin, meterazin, meterazin maleate, meterazine, nipodal, novamin, pasotomin, stemetil, tementil, temetid, vertigon.
Formula: C20H24Cln3S
IUPAC Formula: 2-Chloro-10-[3-(4-Methylpiperazin-1-Yl)propyl]-10h-Phenothiazine
PDB name: 2-Chloro-10-[3-(4-Methylpiperazin-1-Yl)propyl]-10h-Phenothiazine

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
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Information  
Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
  3. 5aer B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing prochlorperazine bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with prochlorperazine bound in the PDB

There is 1 "non-target" protein in the PDB containing the prochlorperazine molecule bound. That is, the UniProt code for the protein is missing or does not match the drug target above.

Protein 1:   UniProt id: P26447 ()  -  Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1
UniProt id: P26447    100 a.a.  
3m0w A,E,H,I   90 a.a. 90   X-ray 2.80 Å
The PDB contains 1 entry of prochlorperazine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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