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DB00428 : streptozocin

Approved drug streptozocin ... 3 targets DB00428

Generic name: streptozocin PDB Het Group: STZ
 
1 structure in PDB
Brand name(s): streptozotocin, strz, streptozocin [usan:inn], streptozocine [inn-french], streptozocinium [latin], streptozocinum [inn-latin], zanosar.
Formula: C8H15N3O7
IUPAC Formula: 3-Methyl-3-Nitroso-1-[(2s,3r,4r,5s,6r)-2,4,5-Trihydroxy-6-(Hydroxymethyl)oxan-3-Yl]urea
PDB name: Streptozotocin

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P11168 (GTR2_HUMAN)  -  Solute carrier family 2, facilitated glucose transporter member 2
UniProt id: P11168    524 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q89ZI2 (OGA_BACTN)  -  O-GlcNAcase BT_4395
UniProt id: Q89ZI2    736 a.a.  
2w4x A   579 a.a. 579   X-ray 2.42 Å
The PDB contains 1 entry of streptozocin bound to this target protein and 19 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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