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DB00417 : penicillin v

Approved drug penicillin v ... 4 targets DB00417

Generic name: penicillin v PDB Het Group: PNV
 
2 structures in PDB
Brand name(s): acipen v, apopen, beepen-vk, beromycin, betapen-vk, calcipen, compocillin v, crystapen v, distaquaine v, eskacillian v, eskacillin v, fenacilin, fenospen, fenoxypen, ledercillin vk, meropenin, oracillin, oratren, ospen, pen-oral, pen-v, pen-vee, pen-vee k, penapar-vk, penicillin vk, penicillin-vk, pfizerpen vk, phenocillin, phenomycilline, phenopenicillin, robicillin, rocilin, stabicillin, uticillin vk, v-cil, v-cillin, v-cillin k, v-cylina, v-cyline, v-tablopen, vebecillin, veetids, veetids '125', veetids '250', veetids '500'.
Formula: C16H18N2O5S
IUPAC Formula: (2s,5r,6r)-3,3-Dimethyl-7-Oxo-6-(2-Phenoxyacetamido)-4-Thia-1-Azabicyclo[3.2.0]heptane-2-
Carboxylic acid
PDB name: (2s,5r,6r)-3,3-Dimethyl-7-Oxo-6-(2-Phenoxyacetamido)-4-Thia-1- Azabicyclo(3.2.0)heptane-2-
Carboxylic acid

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures of the drug molecule bound to its target protein.
Links  
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ChEBI
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Information  
in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Penicillin V results from the inhibition of cell wall synthesis and is mediated through Penicillin V binding to penicillin binding proteins (PBPs). Penicillin V is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.', WIDTH, 240, PADDING, 4, BGCOLOR, '#ffffff')">Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: Q8XJ01 (PBPA_CLOPE)  -  Penicillin-binding proteins 1A/1B
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: Q53707 (Q53707_STAAU)  -  MecA PBP2' (penicillin binding protein 2')
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P24228 (DACB_ECOLI)  -  Penicillin-binding protein 4
UniProt id: P24228    476 a.a.  
2ex9 A   442 a.a. 441   X-ray 1.65 Å
The PDB contains 1 entry of penicillin v bound to this target protein and 6 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 4:   UniProt id: P12256 (PAC_LYSSH)  -  Penicillin acylase
UniProt id: P12256    337 a.a.  
2z71 A,C   330 a.a. 328   X-ray 2.60 Å
The PDB contains 1 entry of penicillin v bound to this target protein and 6 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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