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DB00408 : loxapine

Approved drug loxapine ... 4 targets DB00408

Generic name: loxapine
 
Brand name(s): cloxazepine, dibenzacepin, dibenzoazepine, hydrofluoride 3170, lossapina [dcit], loxapac, loxapin, loxapina [inn-spanish], loxapine [usan:ban:inn], loxapinum [inn-latin], loxepine, loxitane c, loxitane im, oxilapine.
Formula: C18H18Cln3O
IUPAC Formula: 13-Chloro-10-(4-Methylpiperazin-1-Yl)-2-Oxa-9-Azatricyclo[9.4.0.0^{3,8}]pentadeca-
1(11),3(8),4,6,9,12,14-Heptaene

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing loxapine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing loxapine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P28223 (5HT2A_HUMAN)  -  5-hydroxytryptamine 2A receptor
UniProt id: P28223    471 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P28335 (5HT2C_HUMAN)  -  5-hydroxytryptamine 2C receptor
UniProt id: P28335    458 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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