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DB00387 : procyclidine

Approved drug procyclidine ... 4 targets DB00387

Generic name: procyclidine
 
Brand name(s): arpicolin, elorine, kemadrin, kemadrine, lergine, metanin, osnervan, procyclid, procyklidin, prosyklidin, spamol, triciclidina, triciloid, tricoloid, tricyclamol, vagosin.
Formula: C19H29No
IUPAC Formula: 1-Cyclohexyl-1-Phenyl-3-(Pyrrolidin-1-Yl)propan-1-Ol

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P11229 (ACM1_HUMAN)  -  Muscarinic acetylcholine receptor M1
UniProt id: P11229    460 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing procyclidine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P08173 (ACM4_HUMAN)  -  Muscarinic acetylcholine receptor M4
UniProt id: P08173    479 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing procyclidine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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