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DB00384 : triamterene

Approved drug triamterene ... 4 targets DB00384

Generic name: triamterene PDB Het Group: DX2
 
2 structures in PDB
Brand name(s): ademin, ademine, diren, ditak, diucelpin, diurene, dyren, dyrenium, dytac, jatropur, noridil, noridyl, pterofen, pterophene, taturil, teriam, teridin, tri-span, triampur, triamteril, triamteril complex, trispan, triteren, urocaudal.
Formula: C12H11N7
IUPAC Formula: 6-Phenylpteridine-2,4,7-Triamine
PDB name: 6-Phenylpteridine-2,4,7-Triamine

4
There are 4 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P51170 (SCNNG_HUMAN)  -  Amiloride-sensitive sodium channel subunit gamma
UniProt id: P51170    649 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P37088 (SCNNA_HUMAN)  -  Amiloride-sensitive sodium channel subunit alpha
UniProt id: P37088    668 a.a.  
2m3o P     11 a.a. 11   NMR  
There are no PDB entries containing triamterene bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P51168 (SCNNB_HUMAN)  -  Amiloride-sensitive sodium channel subunit beta
UniProt id: P51168    640 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P51172 (SCNND_HUMAN)  -  Amiloride-sensitive sodium channel subunit delta
UniProt id: P51172    638 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with triamterene bound in the PDB

There are 2 "non-target" proteins in the PDB containing the triamterene molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: O76290 ()  -  Pteridine reductase OS=Trypanosoma brucei brucei GN=PTR1 PE=1 SV=1
UniProt id: O76290    267 a.a.  
3bme A,B,C,D   247 a.a. 245   X-ray 1.80 Å
The PDB contains 1 entry of triamterene bound to this protein
Protein 2:   UniProt id: Q581W1 ()  -  Pteridine reductase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) GN=Tb927.8.2210 PE=1 SV=1
UniProt id: Q581W1    368 a.a.  
3jq7 A,B,C,D   247 a.a. 245   X-ray 1.80 Å
The PDB contains 1 entry of triamterene bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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