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DB00382 : tacrine

Approved drug tacrine ... 2 targets DB00382

Generic name: tacrine PDB Het Group: THA
 
5 structures in PDB
Brand name(s): cognex, romotal.
Formula: C13H14N2
IUPAC Formula: 1,2,3,4-Tetrahydroacridin-9-Amine
PDB name: Tacrine

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P22303 (ACES_HUMAN)  -  Acetylcholinesterase
UniProt id: P22303    613 a.a.  
1. 4bdt A     563 a.a. 563   X-ray 3.10 Å
  2. 1clj       538 a.a. 538   Theor. model
  3. 1puv A     538 a.a. 538   Theor. model
  4. 1puw A     538 a.a. 538   Theor. model
  5. 2x8b A     536 a.a. 535   X-ray 2.95 Å
   more ...
There are no PDB entries containing tacrine bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P06276 (CHLE_HUMAN)  -  Cholinesterase
UniProt id: P06276    601 a.a.  
4bds A   524 a.a. 520   X-ray 2.10 Å
The PDB contains 1 entry of tacrine bound to this target protein and 38 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with tacrine bound in the PDB

There is 1 "non-target" protein in the PDB containing the tacrine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P04058 ()  -  Acetylcholinesterase OS=Torpedo californica GN=ache PE=1 SV=2
UniProt id: P04058    585 a.a.  
1acj A   528 a.a. 528   X-ray 2.80 Å
The PDB contains 1 entry of tacrine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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