spacer
spacer

Search 

DB00381 : amlodipine

Approved drug amlodipine ... 9 targets DB00381

Generic name: amlodipine PDB Het Group: 06X
 
2 structures in PDB
Brand name(s): amlocard, amlodis, amvaz, coroval, lipinox, lotrel, norvasc.
Formula: C20H25Cln2O5
IUPAC Formula: 3-Ethyl 5-Methyl 2-[(2-Aminoethoxy)methyl]-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-
Dicarboxylate
PDB name: Amlodipine

9
There are 9 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
RxList
ChEBI
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: Q13936 (CAC1C_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt id: Q13936    2220 a.a.  
1. 3g43 E     68 a.a. 66   X-ray 2.10 Å
  2. 3oxq E,F     64 a.a. 63   X-ray 2.55 Å
  3. 2be6 D     29 a.a. 29   X-ray 2.00 Å
  4. 2lqc B     24 a.a. 22   NMR  
  5. 2f3z B     18 a.a. 16   X-ray 1.60 Å
There are no PDB entries containing amlodipine bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P54289 (CA2D1_HUMAN)  -  Voltage-dependent calcium channel subunit alpha-2/delta-1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q08289 (CACB2_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-2
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q01668 (CAC1D_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1D
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q13698 (CAC1S_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt id: Q13698    1872 a.a.  
2vay B     21 a.a. 21   X-ray 1.94 Å
There are no PDB entries containing amlodipine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 6:   UniProt id: Q00975 (CAC1B_HUMAN)  -  Voltage-dependent N-type calcium channel subunit alpha-1B
UniProt id: Q00975    2338 a.a.  
2lcm A     28 a.a. 28   NMR  
There are no PDB entries containing amlodipine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: Q8IZS8 (CA2D3_HUMAN)  -  Voltage-dependent calcium channel subunit alpha-2/delta-3
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: Q6TME4 (Q6TME4_HUMAN)  -  Voltage-gated calcium channel beta 1 subunit splice variant CavB1d
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing amlodipine bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with amlodipine bound in the PDB

There are 2 "non-target" proteins in the PDB containing the amlodipine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P00178 ()  -  Cytochrome P450 2B4 OS=Oryctolagus cuniculus GN=CYP2B4 PE=1 SV=1
UniProt id: P00178    490 a.a.  
3tmz A   463 a.a. 459   X-ray 2.25 Å
The PDB contains 1 entry of amlodipine bound to this protein
Protein 2:   UniProt id: P20813 ()  -  Cytochrome P450 2B6 OS=Homo sapiens GN=CYP2B6 PE=1 SV=1
UniProt id: P20813    490 a.a.  
3ua5 A,B   465 a.a. 460   X-ray 2.80 Å
The PDB contains 1 entry of amlodipine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer