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DB00372 : thiethylperazine

Approved drug thiethylperazine ... 3 targets DB00372

Generic name: thiethylperazine
 
Brand name(s): norzine, torecan.
Formula: C22H29N3S2
IUPAC Formula: 2-(Ethylsulfanyl)-10-[3-(4-Methylpiperazin-1-Yl)propyl]-10h-Phenothiazine

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
  3. 5aer B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing thiethylperazine bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing thiethylperazine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P21917 (DRD4_HUMAN)  -  D(4) dopamine receptor
UniProt id: P21917    467 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

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