spacer
spacer

Search 

DB00369 : cidofovir

Approved drug cidofovir ... 1 target DB00369

Generic name: cidofovir PDB Het Group: CFV
 
1 structure in PDB
Brand name(s): hpmpc, vistide.
Formula: C8H14N3O6P
IUPAC Formula: ({[(2s)-1-(4-Amino-2-Oxo-1,2-Dihydropyrimidin-1-Yl)-3-Hydroxypropan-2-Yl]oxy}methyl)phosphonic acid
PDB name: [(2r)-1-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3-Hydroxy-Propan-2-Yl]oxymethylphosphonic acid

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
RxList
ChEBI
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P08546 (DPOL_HCMVA)  -  DNA polymerase
UniProt id: P08546    1241 a.a.  
1yyp B     20 a.a. 20   X-ray 2.50 Å
There are no PDB entries containing cidofovir bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with cidofovir bound in the PDB

There is 1 "non-target" protein in the PDB containing the cidofovir molecule bound. That is, the UniProt code for the protein is missing or does not match the drug target above.

Protein 1:   UniProt id: P62617 ()  -  2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase OS=Escherichia coli (strain K12) GN=ispF PE=1 SV=1
UniProt id: P62617    159 a.a.  
3eor A   157 a.a. 156   X-ray 2.90 Å
The PDB contains 1 entry of cidofovir bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer