spacer
spacer

Search 

DB00368 : norepinephrine

Approved drug norepinephrine ... 10 targets DB00368

Generic name: norepinephrine PDB Het Group: LNR
 
4 structures in PDB
Brand name(s): none.
Formula: C8H11No3
IUPAC Formula: 4-[(1r)-2-Amino-1-Hydroxyethyl]benzene-1,2-Diol
PDB name: L-Norepinephrine

10
There are 10 target proteins defined in DrugBank for this drug.
 6 
6 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 3 
There are 3 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
RxList
ChEBI
KEGG drug
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P00439 (PH4H_HUMAN)  -  Phenylalanine-4-hydroxylase
UniProt id: P00439    451 a.a.  
4pah A   308 a.a. 308   X-ray 2.00 Å
The PDB contains 1 entry of norepinephrine bound to this target protein and 16 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P35368 (ADA1B_HUMAN)  -  Alpha-1B adrenergic receptor
UniProt id: P35368    520 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P25100 (ADA1D_HUMAN)  -  Alpha-1D adrenergic receptor
UniProt id: P25100    572 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P08913 (ADA2A_HUMAN)  -  Alpha-2A adrenergic receptor
UniProt id: P08913    449 a.a.  
1. 1hll A     32 a.a. 32   NMR  
  2. 1hof A     32 a.a. 32   NMR  
  3. 1ho9 A     32 a.a. 31   NMR  
  4. 1hod A     32 a.a. 31   NMR  
There are no PDB entries containing norepinephrine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P18089 (ADA2B_HUMAN)  -  Alpha-2B adrenergic receptor
UniProt id: P18089    449 a.a.  
2cva A     32 a.a. 32   Theor. model
There are no PDB entries containing norepinephrine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: P18825 (ADA2C_HUMAN)  -  Alpha-2C adrenergic receptor
UniProt id: P18825    462 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P08588 (ADRB1_HUMAN)  -  Beta-1 adrenergic receptor
UniProt id: P08588    476 a.a.  
2lsq A     25 a.a. 19   NMR  
There are no PDB entries containing norepinephrine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 9:   UniProt id: P07550 (ADRB2_HUMAN)  -  Beta-2 adrenergic receptor
UniProt id: P07550    412 a.a.  
1. 3pds A     442 a.a. 292   X-ray 3.50 Å
  2. 4gbr A     286 a.a. 283   X-ray 3.99 Å
  3. 3kj6 A     222 a.a. 222   X-ray 3.40 Å
  4. 2r4r A     216 a.a. 216   X-ray 3.40 Å
  5. 2r4s A     216 a.a. 216   X-ray 3.40 Å
   more ...
There are no PDB entries containing norepinephrine bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 10:   UniProt id: P13945 (ADRB3_HUMAN)  -  Beta-3 adrenergic receptor
UniProt id: P13945    407 a.a.  
2cdw A     408 a.a. 407   Theor. model
There are no PDB entries containing norepinephrine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with norepinephrine bound in the PDB

There are 3 "non-target" proteins in the PDB containing the norepinephrine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P11086 ()  -  Phenylethanolamine N-methyltransferase OS=Homo sapiens GN=PNMT PE=1 SV=1
UniProt id: P11086    281 a.a.  
3hcd A,B   257 a.a. 257   X-ray 2.39 Å
The PDB contains 1 entry of norepinephrine bound to this protein
Protein 2:   UniProt id: P18153 ()  -  37 kDa salivary gland allergen Aed a 2 OS=Aedes aegypti GN=D7 PE=1 SV=2
UniProt id: P18153    320 a.a.  
3dye A   302 a.a. 288   X-ray 1.75 Å
The PDB contains 1 entry of norepinephrine bound to this protein
Protein 3:   UniProt id: Q9BIH3 ()  -  D7-related 4 protein OS=Anopheles gambiae GN=d7r4 PE=1 SV=1
UniProt id: Q9BIH3    164 a.a.  
2qeo A,B   144 a.a. 144   X-ray 2.31 Å
The PDB contains 1 entry of norepinephrine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer