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DB00358 : mefloquine

Approved drug mefloquine ... 3 targets DB00358

Generic name: mefloquine
 
Brand name(s): lariam.
Formula: C17H16F6N2O
IUPAC Formula: [2,8-Bis(trifluoromethyl)quinolin-4-Yl](piperidin-2-Yl)methanol

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P69905 (HBA_HUMAN)  -  Hemoglobin subunit alpha
UniProt id: P69905    141 a.a.  
1. 1ird A     141 a.a. 141   X-ray 1.25 Å
  2. 2dfo A     141 a.a. 141   X-ray 1.25 Å
  3. 2dfq A,C     141 a.a. 141   X-ray 1.25 Å
  4. 2dn2 A,C     141 a.a. 141   X-ray 1.25 Å
  5. 2dn3 A     141 a.a. 141   X-ray 1.25 Å
   more ...
There are no PDB entries containing mefloquine bound to this target protein, although there are 222 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P29274 (AA2AR_HUMAN)  -  Adenosine A2a receptor
UniProt id: P29274    411 a.a.  
1. 1upe A     304 a.a. 303   Theor. model
  2. 2ydv A     315 a.a. 302   X-ray 2.60 Å
  3. 3vg9 A     297 a.a. 297   X-ray 2.70 Å
  4. 2ydo A     309 a.a. 297   X-ray 3.00 Å
  5. 3vga A     296 a.a. 296   X-ray 3.10 Å
   more ...
There are no PDB entries containing mefloquine bound to this target protein, although there are 14 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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