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DB00357 : aminoglutethimide

Approved drug aminoglutethimide ... 2 targets DB00357

Generic name: aminoglutethimide
 
Brand name(s): cytadren, elipten, orimeten.
Formula: C13H16N2O2
IUPAC Formula: 3-(4-Aminophenyl)-3-Ethylpiperidine-2,6-Dione

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P11511 (CP19A_HUMAN)  -  Cytochrome P450 19A1
UniProt id: P11511    502 a.a.  
1. 3s79 A     452 a.a. 452   X-ray 2.75 Å
  2. 3eqm A     452 a.a. 452   X-ray 2.90 Å
  3. 3s7s A     452 a.a. 452   X-ray 3.21 Å
  4. 4kq8 A     452 a.a. 452   X-ray 3.29 Å
  5. 4gl5 A     452 a.a. 452   X-ray 3.48 Å
   more ...
There are no PDB entries containing aminoglutethimide bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P05108 (CP11A_HUMAN)  -  Cholesterol side-chain cleavage enzyme, mitochondrial
UniProt id: P05108    520 a.a.  
1. 3na1 A,B     472 a.a. 472   X-ray 2.25 Å
  2. 3n9y A,B     471 a.a. 471   X-ray 2.10 Å
  3. 3n9z A,B     470 a.a. 470   X-ray 2.17 Å
  4. 3na0 A,B     470 a.a. 470   X-ray 2.50 Å
There are no PDB entries containing aminoglutethimide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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