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DB00355 : aztreonam

Approved drug aztreonam ... 2 targets DB00355

Generic name: aztreonam PDB Het Group: AZR
 
4 structures in PDB
Brand name(s): azactam, corus 1020, dynabiotic, monobactam, primbactam.
Formula: C13H17N5O8S2
IUPAC Formula: (2s,3s)-3-[(2z)-2-(2-Azaniumyl-1,3-Thiazol-4-Yl)-2-[(1-Carboxy-1-Methylethoxy)imino]acetamido]-2-
Methyl-4-Oxoazetidine-1-Sulfonate
PDB name: 2-({[(1z)-1-(2-Amino-1,3-Thiazol-4-Yl)-2-Oxo-2-{[(2s,3s)-1-Oxo-3-(Sulfoamino)butan-2-
Yl]amino}ethylidene]amino}oxy)-2-Methylpropanoic acid

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 4 
There are 4 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P42971 (PBPC_BACSU)  -  Penicillin-binding protein 3
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P05193 (AMPC_CITFR)  -  Beta-lactamase
UniProt id: P05193    380 a.a.  
1rgy A     360 a.a. 352   X-ray 1.52 Å
There are no PDB entries containing aztreonam bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with aztreonam bound in the PDB

There are 4 "non-target" proteins in the PDB containing the aztreonam molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: G1C794 ()  -  Penicillin-binding protein 1a OS=Acinetobacter baumannii GN=ponA PE=1 SV=1
UniProt id: G1C794    850 a.a.  
3ue0 A,B   598 a.a. 598   X-ray 2.60 Å
The PDB contains 1 entry of aztreonam bound to this protein
Protein 2:   UniProt id: Q46041 ()  -  Beta-lactamase OS=Citrobacter freundii PE=1 SV=1
UniProt id: Q46041    380 a.a.  
1fr6 A,B   361 a.a. 353   X-ray 2.50 Å
The PDB contains 1 entry of aztreonam bound to this protein
Protein 3:   UniProt id: Q47066 ()  -  Beta-lactamase Toho-1 OS=Escherichia coli GN=bla PE=1 SV=1
UniProt id: Q47066    290 a.a.  
2zqc A   261 a.a. 258   X-ray 1.07 Å
The PDB contains 1 entry of aztreonam bound to this protein
Protein 4:   UniProt id: Q51504 ()  -  Penicillin-binding protein 3 OS=Pseudomonas aeruginosa GN=pbpB PE=1 SV=1
UniProt id: Q51504    578 a.a.  
3pbs A   499 a.a. 499   X-ray 2.00 Å
The PDB contains 1 entry of aztreonam bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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