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DB00352 : thioguanine

Approved drug thioguanine ... 1 target DB00352

Generic name: thioguanine PDB Het Group: DX4
 
4 structures in PDB
Brand name(s): lanvis, tabloid, wellcome u3b.
Formula: C5H5N5S
IUPAC Formula: 2-Amino-6,7-Dihydro-3h-Purine-6-Thione
PDB name: 2-Amino-1,9-Dihydro-6h-Purine-6-Thione

1
There is 1 target protein defined in DrugBank for this drug.
 3 
There are 3 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:  

 

Other proteins with thioguanine bound in the PDB

There are 3 "non-target" proteins in the PDB containing the thioguanine molecule bound. That is, the UniProt code for the proteins is missing or does not match the drug target above.

Protein 1:   UniProt id: O76290 ()  -  Pteridine reductase OS=Trypanosoma brucei brucei GN=PTR1 PE=1 SV=1
UniProt id: O76290    267 a.a.  
3bmg A,B,C,D   249 a.a. 249   X-ray 1.90 Å
The PDB contains 1 entry of thioguanine bound to this protein
Protein 2:   UniProt id: P26281 ()  -  2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase OS=Escherichia coli (strain K12) GN=folK PE=1 SV=3
UniProt id: P26281    158 a.a.  
4m5m A   159 a.a. 158   X-ray 1.12 Å
The PDB contains 1 entry of thioguanine bound to this protein
Protein 3:   UniProt id: Q581W1 ()  -  Pteridine reductase, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) GN=Tb927.8.2210 PE=1 SV=1
UniProt id: Q581W1    368 a.a.  
3jqa A,B,C,D   249 a.a. 249   X-ray 1.90 Å
The PDB contains 1 entry of thioguanine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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