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DB00342 : terfenadine

Approved drug terfenadine ... 3 targets DB00342

Generic name: terfenadine
 
Brand name(s): aldaban, allerplus, cyater, seldane, teldane, teldanex, terdin, terfex, triludan.
Formula: C32H41No2
IUPAC Formula: 1-(4-Tert-Butylphenyl)-4-[4-(Hydroxydiphenylmethyl)piperidin-1-Yl]butan-1-Ol

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing terfenadine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: Q12809 (KCNH2_HUMAN)  -  Potassium voltage-gated channel subfamily H member 2
UniProt id: Q12809    1158 a.a.  
1. 2l0w A     135 a.a. 134   NMR  
  2. 2l1m A     135 a.a. 134   NMR  
  3. 2l4r A     135 a.a. 134   NMR  
  4. 4hp9 A     119 a.a. 119   X-ray 2.12 Å
  5. 4hqa A     110 a.a. 110   X-ray 1.96 Å
   more ...
There are no PDB entries containing terfenadine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing terfenadine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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