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DB00338 : omeprazole

Approved drug omeprazole ... 1 target DB00338

Generic name: omeprazole PDB Het Group: 1C6
 
3 structures in PDB
Brand name(s): antra, audazol, aulcer, belmazol, ceprandal, danlox, demeprazol, desec, dizprazol, dudencer, elgam, emeproton, epirazole, erbolin, exter, gasec, gastrimut, gastroloc, gibancer, indurgan, inhibitron, inhipump, lensor, logastric, lomac, losec, mepral, miol, miracid, mopral, morecon, nilsec, nopramin, ocid, olexin, omapren, omebeta 20, omed, omegast, omepral, omeprazon, omeprol, omesek, omezol, omezolan, omid, omisec, omizac, ompanyt, ortanol, osiren, ozoken, paprazol, parizac, pepticum, pepticus, peptilcer, prazentol, prazidec, prazolit, prilosec, procelac, proclor, prysma, ramezol, regulacid, result, sanamidol, secrepina, tedec ulceral, ulceral, ulcesep, ulcometion, ulcozol, ulcsep, ulsen, ultop, ulzol, victrix, zefxon, zegerid, zepral, zimor, zoltum.
Formula: C17H19N3O3S
IUPAC Formula: 6-Methoxy-2-{[(4-Methoxy-3,5-Dimethylpyridin-2-Yl)methane]sulfinyl}-1h-1,3-Benzodiazole
PDB name: 6-Methoxy-2-{[(4-Methoxy-3,5-Dimethylpyridin-2-Yl)methyl]sulfanyl}-1h-Benzimidazole

1
There is 1 target protein defined in DrugBank for this drug.
 3 
There are 3 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
Links  
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Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P20648 (ATP4A_HUMAN)  -  Potassium-transporting ATPase alpha chain 1
UniProt id: P20648    1035 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain

 

Other proteins with omeprazole bound in the PDB

There is 1 "non-target" protein in the PDB containing the omeprazole molecule bound. That is, the UniProt code for the protein is missing or does not match the drug target above.

Protein 1:   UniProt id: P14779 ()  -  Bifunctional P-450/NADPH-P450 reductase OS=Bacillus megaterium GN=cyp102A1 PE=1 SV=2
UniProt id: P14779    1048 a.a.  
1. 4kew A,B   450 a.a. 449   X-ray 1.89 Å
  2. 4o4p A,B   450 a.a. 448   X-ray 1.83 Å
  3. 4key A,B   450 a.a. 448   X-ray 2.05 Å
The PDB contains 3 entries of omeprazole bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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