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DB00335 : atenolol

Approved drug atenolol ... 1 target DB00335

Generic name: atenolol PDB Het Group: 2TN
 
3 structures in PDB
Brand name(s): aircrit, alinor, altol, anselol, antipressan, apo-atenolol, atcardil, atecard, atehexal, atenblock, atendol, atenet, ateni, atenil, atenol, atenol 1a pharma, atenol al, atenol acis, atenol atid, atenol ct, atenol cophar, atenol fecofar, atenol gnr, atenol gador, atenol genericon, atenol heumann, atenol msd, atenol nm pharma, atenol nordic, atenol pb, atenol quesada, atenol stada, atenol tika, atenol trom, atenol von ct, atenol-mepha, atenol-ratiopharm, atenol-wolff, atenolin, atenomel, atereal, aterol, betablok, betacard, betasyn, betatop ge, blocotenol, blokium, cardaxen, cardiopress, corotenol, cuxanorm, duraatenolol, duratenol, evitocor, farnormin, felo-bits, hipres, hypoten, ibinolo, internolol, jenatenol, juvental, lo-ten, loten, lotenal, myocord, normalol, normiten, noten, oraday, ormidol, panapres, plenacor, premorine, prenolol, prenormine, prinorm, scheinpharm atenol, seles beta, selobloc, serten, servitenol, stermin, tenidon, teno-basan, tenobloc, tenoblock, tenolol, tenoprin, tenormin, tenormine, tensimin, tredol, unibloc, uniloc, vascoten, vericordin, wesipin, xaten.
Formula: C14H22N2O3
IUPAC Formula: 2-(4-{2-Hydroxy-3-[(Propan-2-Yl)amino]propoxy}phenyl)acetamide
PDB name: 2-(4-(2-Hydroxy-3-(Isopropylamino)propoxy)phenyl)ethanamide

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 3 
There are 3 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P08588 (ADRB1_HUMAN)  -  Beta-1 adrenergic receptor
UniProt id: P08588    476 a.a.  
2lsq A     25 a.a. 19   NMR  
There are no PDB entries containing atenolol bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with atenolol bound in the PDB

There are 2 "non-target" proteins in the PDB containing the atenolol molecule bound. That is, the UniProt code for the proteins is missing or does not match the drug target above.

Protein 1:   UniProt id: P24627 ()  -  Lactotransferrin OS=Bos taurus GN=LTF PE=1 SV=2
UniProt id: P24627    707 a.a.  
2nuv A   341 a.a. 339   X-ray 2.25 Å
The PDB contains 1 entry of atenolol bound to this protein
Protein 2:   UniProt id: P59071 ()  -  Basic phospholipase A2 VRV-PL-VIIIa OS=Daboia russelii PE=1 SV=1
UniProt id: P59071    120 a.a.  
1. 2otf A   121 a.a. 120   X-ray 1.95 Å
  2. 2oub A   121 a.a. 120   X-ray 2.75 Å
The PDB contains 2 entries of atenolol bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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