spacer
spacer

Search 

DB00332 : ipratropium bromide

Approved drug ipratropium bromide ... 3 targets DB00332

Generic name: ipratropium bromide
 
Brand name(s): aerodose, aerovent, apo-ipravent, apovent, atronase, atrovent, atrovent aerosol, atrovent hfa, atrovent nasal, bitrop, disne-asmol, ipravent, ipvent, kendral-ipratropium, narilet, rhinotrop, rhinovent, rinatec, rinoberen, rinovagos, vagos.
Formula: C20H30Brno3
IUPAC Formula: (1r,3r,5s,8r)-3-[(3-Hydroxy-2-Phenylpropanoyl)oxy]-8-Methyl-8-(Propan-2-Yl)-8-
Azabicyclo[3.2.1]octan-8-Ium bromide

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
RxList
ChEBI
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P11229 (ACM1_HUMAN)  -  Muscarinic acetylcholine receptor M1
UniProt id: P11229    460 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing ipratropium bromide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing ipratropium bromide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer

  spacer

spacer