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DB00319 : piperacillin

Approved drug piperacillin ... 4 targets DB00319

Generic name: piperacillin PDB Het Group: WPP
 
1 structure in PDB
Brand name(s): pipracil.
Formula: C23H27N5O7S
IUPAC Formula: (2s,5r,6r)-6-[(2r)-2-{[(4-Ethyl-2,3-Dioxopiperazin-1-Yl)carbonyl]amino}-2-Phenylacetamido]-3,3-
Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]heptane-2-Carboxylic acid
PDB name: Piperacillin

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Information  
in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Piperacillin results from the inhibition of cell wall synthesis and is mediated through Piperacillin binding to penicillin binding proteins (PBPs). Piperacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.', WIDTH, 240, PADDING, 4, BGCOLOR, '#ffffff')">Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: Q75Y35 (Q75Y35_STREE)  -  Penicillin-binding protein 3
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P0A3M6 (PBP2_STRR6)  -  Penicillin-binding protein 2B
UniProt id: P0A3M6    679 a.a.  
2waf A     619 a.a. 617   X-ray 3.29 Å
There are no PDB entries containing piperacillin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: Q8DNB6 (Q8DNB6_STRR6)  -  Penicillin-binding protein 2a
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q7CRA4 (Q7CRA4_STRR6)  -  Penicillin-binding protein 1b
UniProt id: Q7CRA4    820 a.a.  
1. 2y2m A     471 a.a. 457   X-ray 1.62 Å
  2. 2y2o A     471 a.a. 457   X-ray 1.88 Å
  3. 2y2j A     470 a.a. 456   X-ray 2.06 Å
  4. 2xd5 A,B     469 a.a. 456   X-ray 2.50 Å
  5. 2y2k A     469 a.a. 455   X-ray 2.09 Å
   more ...
There are no PDB entries containing piperacillin bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with piperacillin bound in the PDB

There is 1 "non-target" protein in the PDB containing the piperacillin molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q9L5C8 ()  -  Beta-lactamase OS=Escherichia coli GN=blaCTX-M-9a PE=1 SV=1
UniProt id: Q9L5C8    290 a.a.  
3q07 A,B   262 a.a. 261   X-ray 1.50 Å
The PDB contains 1 entry of piperacillin bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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