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DB00308 : ibutilide

Approved drug ibutilide ... 10 targets DB00308

Generic name: ibutilide
 
Brand name(s): corvert.
Formula: C20H36N2O3S
IUPAC Formula: N-(4-{4-[Ethyl(heptyl)amino]-1-Hydroxybutyl}phenyl)methanesulfonamide

10
There are 10 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q14654 (KCJ11_HUMAN)  -  ATP-sensitive inward rectifier potassium channel 11
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: Q13936 (CAC1C_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt id: Q13936    2220 a.a.  
1. 3g43 E     68 a.a. 66   X-ray 2.10 Å
  2. 3oxq E,F     64 a.a. 63   X-ray 2.55 Å
  3. 2be6 D     29 a.a. 29   X-ray 2.00 Å
  4. 2lqc B     24 a.a. 22   NMR  
  5. 2f3z B     18 a.a. 16   X-ray 1.60 Å
There are no PDB entries containing ibutilide bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q02641 (CACB1_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-1
UniProt id: Q02641    598 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q12809 (KCNH2_HUMAN)  -  Potassium voltage-gated channel subfamily H member 2
UniProt id: Q12809    1158 a.a.  
1. 2l0w A     135 a.a. 134   NMR  
  2. 2l1m A     135 a.a. 134   NMR  
  3. 2l4r A     135 a.a. 134   NMR  
  4. 4hp9 A     119 a.a. 119   X-ray 2.12 Å
  5. 4hqa A     110 a.a. 110   X-ray 1.96 Å
   more ...
There are no PDB entries containing ibutilide bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P54289 (CA2D1_HUMAN)  -  Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt id: P54289    1103 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: Q06432 (CCG1_HUMAN)  -  Voltage-dependent calcium channel gamma-1 subunit
UniProt id: Q06432    222 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: O00180 (KCNK1_HUMAN)  -  Potassium channel subfamily K member 1
UniProt id: O00180    335 a.a.  
3ukm A,B,C,D     252 a.a. 249   X-ray 3.40 Å
There are no PDB entries containing ibutilide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 8:   UniProt id: Q9Y257 (KCNK6_HUMAN)  -  Potassium channel subfamily K member 6
UniProt id: Q9Y257    313 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: Q9H252 (KCNH6_HUMAN)  -  Potassium voltage-gated channel subfamily H member 6
UniProt id: Q9H252    994 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: Q9NS40 (KCNH7_HUMAN)  -  Potassium voltage-gated channel subfamily H member 7
UniProt id: Q9NS40    1196 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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